Hum. Reprod. Advance Access originally published online on August 5, 2005
Human Reproduction 2005 20(12):3328-3332; doi:10.1093/humrep/dei221
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Metabolic syndrome in young Czech women with polycystic ovary syndrome
áková1
rámková1indelka3,
krha3
1 Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic, 2 Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic and 3 Department of Internal Medicine, Charles University, U Nemocnice 1, Prague 2, 120 00 Czech Republic
Dr Gustav indelka died in 2001.
4 To whom correspondence should be addressed. E-mail: jvrbikova{at}endo.cz
METHODS: Sixty-nine young women with polycystic ovary syndrome (PCOS) [age 25.2 6 4.7 years, with body mass index (BMI) 24.3 6 4.8 kg/m2; mean 6 SD] and 73 age-matched healthy females (BMI 22.3 6 3.3 kg/m2; mean 6 SD) were evaluated for the occurrence of features of metabolic syndrome according to the Adult Treatment Panel III. RESULTS: Overt metabolic syndrome (the presence of three and more risk factors) was not more common in PCOS women (1/64, 1.6%) than in healthy controls (0/73, 0%). On the other hand, in nearly 50% of PCOS women isolated features of metabolic syndrome, most often a decrease in high-density lipoprotein (HDL) cholesterol, were found. Women with at least one feature of metabolic syndrome were, in comparison with women without any of these features, significantly more obese (P = 0.0001), with lower insulin sensitivity (P = 0.05). When comparing PCOS women according to the degree of insulin sensitivity, as determined by euglycaemic clamp, isolated features of metabolic syndrome were found in 8/17 women above the upper quartile, compared with 11/16 women below the lower quartile of insulin sensitivity (P = 0.20). CONCLUSIONS: Overt metabolic syndrome is only rarely encountered in young Czech females affected by PCOS but its isolated features are relatively frequent, both in young PCOS patients and in age-matched control women.
Key words: euglycaemic clamp/insulin resistance/metabolic syndrome/polycystic ovary
Submitted May 14, 2005; resubmitted June 17, 2005; ; accepted June 29, 2005
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