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Hum. Reprod. Advance Access originally published online on July 29, 2005
Human Reproduction 2005 20(12):3510-3513; doi:10.1093/humrep/dei233
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Serum adiponectin concentrations are decreased in women with endometriosis

Yuri Takemura, Yutaka Osuga1, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Chieko Morimoto, Yasushi Hirota, Osamu Yoshino, Tetsu Yano and Yuji Taketani

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

1 To whom correspondence should be addressed. E-mail: yutakaos-tky{at}umin.ac.jp

BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 µg/ml; interquartile range, 10.2 – 16.7) were significantly lower than those of the women without endometriosis (15.9 µg/ml, 13.5 – 19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = – 0.307, P = 0.006) and adhesion scores (R = – 0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis.

Key words: adiponectin/endometriosis


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