Skip Navigation


Hum. Reprod. Advance Access originally published online on December 23, 2004
Human Reproduction 2005 20(3):629-635; doi:10.1093/humrep/deh682
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/3/629    most recent
deh682v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hugues, J.N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hugues, J.N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction Vol. 20 No. 3 © The Author 2004; all rights reserved

Does the addition of recombinant LH in WHO group II anovulatory women over-responding to FSH treatment reduce the number of developing follicles? A dose-finding study

J.N. Hugues1,7, J. Soussis2, I. Calderon3, J. Balasch4, R.A. Anderson5 and A. Romeu6 on behalf of the Recombinant LH Study Group*

1 Center of Reproductive Medicine, Hôpital Jean Verdier, Bondy, France, 2 IVF & Genetics, Athens, Greece, 3 Lin Professional Clinic, Haifa, Israel, 4 Hospital Clinic de Barcelona, Barcelona, Spain, 5 Edinburgh Royal Infirmary, Edinburgh, UK and 6 Hospital Universitario La Fe, Valencia, Spain

7 To whom correspondence should be addressed at: Center of Reproductive Medicine, Hôpital Jean Verdier, Av du 14 Juillet, Bondy, 93143, France. Email: jean-noel.hugues{at}jvr.ap-hop-paris.fr

BACKGROUND: In anovulatory women undergoing ovulation induction, addition of recombinant human LH (rLH) to FSH treatment may promote the dominance of a leading follicle when administered in the late follicular phase. The objective of this study was to find the optimal dose of rLH that can maintain the growth of a dominant follicle, whilst causing atresia of secondary follicles. METHODS: Women with infertility due to anovulation and over-responding to FSH treatment were randomized to receive, in addition to 37.5 IU recombinant human FSH (rFSH), either placebo or different doses of rLH (6.8, 13.6, 30 or 60 µg) daily for a maximum of 7 days. The primary efficacy endpoint was the proportion of patients who had exactly one follicle ≥16 mm on hCG day. RESULTS: Among 153 enrolled patients, the five treatment groups were similar in terms of baseline characteristics. The proportion of patients with exactly one follicle ≥16 mm ranged from 13.3% in the placebo group to 32.1% in the 30 µg rLH group (P=0.048). The pregnancy rate ranged from 10.3% in the 60 µg group to 28.6% in the 30 µg rLH group. Adverse events were similar between groups. CONCLUSIONS: In patients over-responding to FSH during ovulation induction, doses of up to 30 µg rLH/day appear to increase the proportion of patients developing a single dominant follicle (≥16 mm). Our data support the ‘LH ceiling’ concept whereby addition of rLH is able to control development of the follicular cohort.

Key words: anovulation/follicular growth/recombinant human FSH/recombinant human LH

* Recombinant LH Study Group: Prof. D.Healy, Clayton, Australia; Dr G.Hughes, Randwick, Australia; Dr T.Tulandi, Montreal, Canada; Dr A.N.Andersen, Copenhagen, Denmark; Dr E.Varila, Tampere, Finland; Dr C.Avril, Bois Guillaume, France; Prof. J.N.Hugues, Dr I.Cedrin Durnerin, Bondy, France; Dr Y.Michapoulos, Athens, Greece; Dr J.Soussis, Athens, Greece; Dr I.Calderon, Haifa, Israel; Prof. J.Itzkovitz, Haifa, Israel; Prof. G.Melis, Sardinia, Italy; Prof. J.Balasch, Dr F.Fábregues, Barcelona, Spain; Dr V.Caballero Fernandez, Seville, Spain; Dr A.de la Fuente, Madrid, Spain; Prof. A.Romeu, Valencia, Spain; Assoc. Prof. O.Gökmen, Ankara, Turkey; Prof. R.Pabuçcu, Ankara, Turkey; Dr R.A.Anderson, Edinburgh, UK; Prof. D.Barlow, Oxford, UK; Dr R.Fleming, Glasgow, UK; Dr S.Power, London, UK.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
C. Hayden
GnRH analogues: applications in assisted reproductive techniques
Eur. J. Endocrinol., December 1, 2008; 159(suppl_1): S17 - S25.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Balen, P. Platteau, A. N. Andersen, P. Devroey, L. Helmgaard, J.-C. Arce, and for the Bravelle Ovulation Induction (BOI) Study G
Highly purified FSH is as efficacious as recombinant FSH for ovulation induction in women with WHO Group II anovulatory infertility: a randomized controlled non-inferiority trial
Hum. Reprod., July 1, 2007; 22(7): 1816 - 1823.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.