Skip Navigation


Hum. Reprod. Advance Access originally published online on December 17, 2004
Human Reproduction 2005 20(4):848-851; doi:10.1093/humrep/deh696
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/4/848    most recent
deh696v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pietrowski, D.
Right arrow Articles by Tempfer, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pietrowski, D.
Right arrow Articles by Tempfer, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2004. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene

Detlef Pietrowski1,3, Hertha Bettendorf1, Eva-Katrin Riener1, Christoph Keck1, Lukas A. Hefler2, Johannes C. Huber2 and Clemens Tempfer1,2

1 Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Freiburg, Germany and 2 Department of Obstetrics and Gynecology, University of Vienna School of Medicine, Vienna, Austria

3 To whom correspondence should be addressed at: University of Freiburg School of Medicine, Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany. Email: pietrowski{at}frk.ukl.uni-freiburg.de

BACKGROUND: The p53 tumour suppressor gene is a well-known factor regulating apoptosis in a wide variety of cells and tissues. Alterations in the p53 gene are among the most common genetic changes in human cancers. In addition, recent data provide evidence that p53 plays a critical role in mediating pregnancy by regulating steroid hormone activation. In idiopathic recurrent miscarriages (IRM), causes and associations are much debated as the exact pathophysiological mechanisms are unknown. In this study, we assess whether an established polymorphism in the p53 gene is associated with the occurrence of IRM. METHODS: Genotyping was performed by PCR-based amplification of the p53 Arg and Pro variants at codon 72 in 175 cases of IRM and 143 controls. RESULTS: We observed a statistically significant association between carriage of the Pro allele and the occurrence of IRM (P=0.03, odds ratio 1.49, confidence interval 1.04–2.14). Distribution of genotypes was in Hardy–Weinberg equilibrium. CONCLUSIONS: Our results indicate an over-representation of the Pro allele of the p53 gene in women with IRM, giving support to the theory that p53 has a potential role during pregnancy.

Key words: apoptosis/genotyping/idiopathic recurrent miscarriage/p53/pregnancy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.