Hum. Reprod. Advance Access originally published online on January 7, 2005
Human Reproduction 2005 20(4):923-927; doi:10.1093/humrep/deh688
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
High reproducibility of serum anti-Müllerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status
Departments of 1 Obstetrics and Gynecology and Reproductive Medicine, 2 Biochemistry and Hormonology, Clamart and 3 INSERM U569 Epidemiology, Kremlin-Bicêtre, France
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology and Reproductive Medicine, Hôpital Antoine Béclère, 157, rue de la Porte de Trivaux, 92141, Clamart, France. Email: renato.fanchin{at}abc.ap-hop-paris.fr
BACKGROUND: Our aim was to compare the intercycle reproducibility of serum anti-Müllerian hormone (AMH) measurements with that of other markers of ovarian follicular status. METHODS: Forty-seven normo-ovulatory, infertile women underwent serum AMH, inhibin B, estradiol and FSH measurements and early antral follicle (2–12 mm in diameter) counts by transvaginal ultrasound on cycle day 3 during three consecutive menstrual cycles. Reproducibility of measurements was estimated using intra-class correlation coefficient (ICC) calculation. We also assessed the number of replicate measurements theoretically needed to reach satisfactory reliability of results. RESULTS: Serum AMH showed significantly higher reproducibility (ICC, 0.89; 95% confidence interval, 0.83–0.94) than inhibin B (0.76; 0.66–0.86; P<0.03), estradiol (0.22; 0.03–0.41; P<0.0001) and FSH levels (0.55; 0.39–0.71; P<0.01), and early antral follicle counts (0.73; 0.62–0.84; P<0.001), and reached satisfactory reliability with a single measurement. CONCLUSIONS: The improved cycle-to-cycle consistency of AMH as compared with other markers of ovarian follicular status is in keeping with its peculiar production by follicles at several developmental stages and further supports its role as a cost-effective, reliable marker of ovarian fertility potential.
Key words: anti-Müllerian hormone/intercycle variability/Müllerian-inhibiting substance/reproducibility
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. A. H. Knauff, M. J. C. Eijkemans, C. B. Lambalk, M. J. ten Kate-Booij, A. Hoek, C. C. M. Beerendonk, J. S. E. Laven, A. J. Goverde, F. J. M. Broekmans, A. P. N. Themmen, et al. Anti-Mullerian Hormone, Inhibin B, and Antral Follicle Count in Young Women with Ovarian Failure J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 786 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.H. de Koning and C.B. Lambalk Reply: Managing IVF in women with consistently or variably elevated early follicular phase FSH Hum. Reprod., March 1, 2009; 24(3): 758 - 758. [Full Text] [PDF]
|
|
|
|
 |
|
 J.L.H. Ireland, D. Scheetz, F. Jimenez-Krassel, A.P.N. Themmen, F. Ward, P. Lonergan, G.W. Smith, G.I. Perez, A.C.O. Evans, and J.J. Ireland Antral Follicle Count Reliably Predicts Number of Morphologically Healthy Oocytes and Follicles in Ovaries of Young Adult Cattle Biol Reprod, December 1, 2008; 79(6): 1219 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van Disseldorp, M. J. Faddy, A. P. N. Themmen, F. H. de Jong, P. H. M. Peeters, Y. T. van der Schouw, and F. J. M. Broekmans Relationship of Serum Antimullerian Hormone Concentration to Age at Menopause J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2129 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gnoth, A.N. Schuring, K. Friol, J. Tigges, P. Mallmann, and E. Godehardt Relevance of anti-Mullerian hormone measurement in a routine IVF program Hum. Reprod., June 1, 2008; 23(6): 1359 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Chen, W.-S. Yang, C.-L. Chen, M.-Y. Wu, Y.-S. Yang, and H.-N. Ho The relationship between anti-Mullerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome Hum. Reprod., April 1, 2008; 23(4): 952 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lie Fong, P.J. Lugtenburg, I. Schipper, A.P.N. Themmen, F.H. de Jong, P. Sonneveld, and J.S.E. Laven Anti-mullerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies Hum. Reprod., March 1, 2008; 23(3): 674 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. van Beek, M. M. van den Heuvel-Eibrink, J. S. E. Laven, F. H. de Jong, A. P. N. Themmen, F. G. Hakvoort-Cammel, C. van den Bos, H. van den Berg, R. Pieters, and S. M. P. F. de Muinck Keizer-Schrama Anti-Mullerian Hormone Is a Sensitive Serum Marker for Gonadal Function in Women Treated for Hodgkin's Lymphoma during Childhood J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3869 - 3874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Hale, X. Zhao, C. L. Hughes, H. G. Burger, D. M. Robertson, and I. S. Fraser Endocrine Features of Menstrual Cycles in Middle and Late Reproductive Age and the Menopausal Transition Classified According to the Staging of Reproductive Aging Workshop (STRAW) Staging System J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3060 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fanchin, D. H. Mendez Lozano, N. Frydman, A. Gougeon, N. di Clemente, R. Frydman, and J. Taieb Anti-Mullerian Hormone Concentrations in the Follicular Fluid of the Preovulatory Follicle Are Predictive of the Implantation Potential of the Ensuing Embryo Obtained by in Vitro Fertilization J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1796 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kinney, J. Kline, A. Kelly, M.L. Reuss, and B. Levin Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years Hum. Reprod., April 1, 2007; 22(4): 1175 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. McIlveen, J.D. Skull, and W.L. Ledger Evaluation of the utility of multiple endocrine and ultrasound measures of ovarian reserve in the prediction of cycle cancellation in a high-risk IVF population Hum. Reprod., March 1, 2007; 22(3): 778 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Al-Qahtani and N. P. Groome Anti-Mullerian Hormone: Cinderella Finds New Admirers. J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3760 - 3762. [Full Text] [PDF]
|
|
|
|
|
|
W. J. K. Hehenkamp, C. W. N. Looman, A. P. N. Themmen, F. H. de Jong, E. R. te Velde, and F. J. M. Broekmans Anti-Mullerian Hormone Levels in the Spontaneous Menstrual Cycle Do Not Show Substantial Fluctuation J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4057 - 4063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.A. Anderson, A.P.N. Themmen, A.A. -Qahtani, N.P. Groome, and D.A. Cameron The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer Hum. Reprod., October 1, 2006; 21(10): 2583 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ebner, M. Sommergruber, M. Moser, O. Shebl, E. Schreier-Lechner, and G. Tews Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles Hum. Reprod., August 1, 2006; 21(8): 2022 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pigny, S. Jonard, Y. Robert, and D. Dewailly Serum Anti-Mullerian Hormone as a Surrogate for Antral Follicle Count for Definition of the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 941 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Visser, F. H de Jong, J. S E Laven, and A. P N Themmen Anti-Mullerian hormone: a new marker for ovarian function Reproduction, January 1, 2006; 131(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|