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Hum. Reprod. Advance Access originally published online on February 3, 2005
Human Reproduction 2005 20(4):965-969; doi:10.1093/humrep/deh690
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome

D. Söderlund1, P. Canto1, S. Carranza-Lira2 and J.P. Méndez1,3

1 Research Unit in Developmental Biology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F. (06703), México, 2 Gynecologic Endocrinology Service, Hospital de Ginecología y Obstetricia ‘Luis Castelazo Ayala’, Instituto Mexicano del Seguro Social, México, D.F. (01090), México

3 To whom correspondence should be addressed at: Unidad de Investigación Médica en Biología del Desarrollo, Coordinación de Investigación en Salud, Coahuila #5, Colonia Roma, C.P. 06703, Apartado Postal A-047, México, D.F., México. Email: jpmb{at}servidor.unam.mx or Email: teodorost{at}yahoo.com

BACKGROUND: Etiology and inheritance pattern in polycystic ovary syndrome (PCOS) remain uncertain. Granulosa cells from follicles of women with PCOS have little, if any, aromatase (encoded by the CYP19 gene) activity; follicles contain low levels of estradiol, P450arom mRNA and aromatase stimulating bioactivity. Mice with targeted disruption of the CYP19 gene present cystic follicles. It has been proposed that chronic exposure to high levels of LH, because of aromatase deficiency, determines the development of ovarian cysts. Herein, we investigated if mutations in the CYP19 gene and/or its ovary promoter are causal in patients with PCOS. METHODS: Twenty-five patients with PCOS and 50 control women were studied. PCR analysis of genomic DNA and complete sequence of all exons of the aromatase gene and its ovary promoter were performed. RESULTS: No heterozygous or homozygous mutant alleles were present in any of the patients studied. CONCLUSIONS: In the population studied, mutations of the P450arom gene or its promoter are not the cause of PCOS. However, these findings do not preclude the possible importance of an aromatase disorder in PCOS etiology. Variations in aromatase complex function could play a role in PCOS etiology, but the determinants of such variations might be located in other genes.

Key words: aromatase deficiency/aromatase gene/mutation/polycystic ovary syndrome/polymorphism


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