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Hum. Reprod. Advance Access originally published online on January 21, 2005
Human Reproduction 2005 20(4):970-973; doi:10.1093/humrep/deh715
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles

Piotr I. Roszkowski1, Monika Sankowska2, Agnieszka Jalbrzykowska2, Dariusz Radomski3, Katarzyna Dragowska1, Rafal Ploski4 and Jacek Malejczyk5,6

1 2nd Department of Gynaecology and Obstetrics, 2 Department of Clinical Immunology, Institute of Transplantology, Warsaw Medical University, PL-02004 Warsaw, Poland, 3 Division of Nuclear and Medical Electronics, Warsaw University of Technology, PL-00665 Warsaw, Poland, 4 Human Molecular Genetics Laboratory of Department of Forensic Medicine and Department of Childhood Diabetes and Birth Defects and 5 Laboratory for Molecular Cell Biology, Department of Histology and Embryology, Centre of Biostructure Research, Warsaw Medical University, PL-02004 Warsaw, Poland

6 To whom correspondence should be addressed at: Laboratory for Molecular Cell Biology, Department of Histology and Embryology, Centre of Biostructure Research, Warsaw Medical University, Chalubinskiego 5, PL-02004 Warsaw, Poland. Email: jmalej{at}ib.amwaw.edu.pl

BACKGROUND: Endometriosis is associated with inflammatory autoimmune reactions; however, aetiopathogenesis of the disease is still poorly understood. While autoimmune disorders are often associated with particular HLA alleles, the possible involvement of HLA in the aetiopathogenesis of endometriosis is still a subject of controversy. The aim of the study was to examine the distribution of HLA-DRB1 alleles in women with endometriosis. To ensure homogeneity of the studied group, only women with ovarian endometrial cysts were included. METHODS: The study included 65 Polish patients of Caucasian origin in whom ovarian endometriosis had been confirmed by laparoscopic and histopathological examinations. HLA-DRB1 alleles were typed using a reverse slot blot method. A frequency of particular HLA-DRB1 alleles in patients was compared with that of a control group of 700 unrelated ethnically matched individuals as well as 193 age-matched women without endometriosis. RESULTS: No statistically significant differences were found in the distribution of HLA-DRB1 alleles in patients with ovarian endometriosis as compared with control populations. CONCLUSIONS: The results of the present study show that ovarian endometriosis is not associated with particular HLA-DRB1 allele(s). This may suggest that aetiology of this form of endometriosis may be not primarily associated with class II HLA-mediated autoimmune reactions.

Key words: autoimmunity/endometriosis/HLA-DRB1 alleles/major histocompatibility complex


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D. H. Whang, S. H. Kim, Y. M. Choi, M. H. Park, J. H. Noh, and Y. B. Kim
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