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Hum. Reprod. Advance Access originally published online on April 7, 2005
Human Reproduction 2005 20(5):1379-1385; doi:10.1093/humrep/deh777
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Française d'Oncologie Gynécologique)

Philippe Morice1,8, Eric Leblanc2, Annie Rey1, Marc Baron3, Denis Querleu4, Jérôme Blanchot5, Pierre Duvillard1, Catherine Lhommé1, Damienne Castaigne1, Jean Marc Classe6, Pascal Bonnier7 and GCCLCC6 and SFOG7

1 Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, 2 Centre Oscar Lambret, 3 rue Frédéric Combemale, 59020 Lille, 3 Centre Henri Becquerel, Rue d'Amiens, 76038 Rouen, 4 Institut Claudius Regaud, 20–24 rue du Pont Saint Pierre, 31052 Toulouse, 5 Centre Eugene Marquis, Rue de la Bataille de Flandre Dunkerque, 35042 Rennes, 6 Groupe des Chirurgiens de Centre de Lutte Contre le Cancer and 7 Société Française d'Oncologie Gynécologique, France

8 To whom correspondence should be addressed at: Service de Chirurgie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France. Email: morice{at}igr.fr

BACKGROUND: Results of conservative management of epithelial ovarian cancer (EOC) remain controversial in the literature. The aim of this study was to assess the clinical outcomes and fertility following fertility-sparing surgical management of EOC in a retrospective multicentre study. METHODS: A multicentre retrospective study was performed by members of two French groups. Six inclusion criteria were defined: (i) Histological review by the same pathologist; (ii) age ≤40 years; (iii) conservative management; (iv) complete peritoneal staging; (v) delivery of a platinum-based chemotherapy in stage ≥IC; and (vi) follow-up >1 year. RESULTS: Thirty-four patients fulfilled the inclusion criteria: 30 had stage IA disease; three had stage IC and one had stage IIA. Eleven patients had recurrence: 10 patients had invasive disease and one had borderline recurrence. Among 10 patients with invasive recurrence, initial stage and grade were: stage IA G1, n=1; stage IA G2, n=4; stage IA G3, n=1; and stage≥IC, n=4. All patients with stage > IA had recurrence. Ten pregnancies were observed in nine patients. CONCLUSION: Conservative surgery for patients with EOC could be considered in young patients with stage IA G1 disease. This procedure should not be performed in patients with FIGO stage > IA.

Key words: conservative surgery/epithelial ovarian tumour/pregnancy/recurrence/restaging surgery


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