Hum. Reprod. Advance Access originally published online on March 17, 2005
Human Reproduction 2005 20(6):1493-1503; doi:10.1093/humrep/deh801
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Compartmental distinctions in uterine Muc-1 expression during early pregnancy in cynomolgous macaque (Macaca fascicularis) and baboon (Papio anubis)
1 Department of Biological Sciences, University of Delaware, Newark, DE 19716, 2 Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616 and 3 Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
4 To whom correspondence should be addressed. Email: dcarson{at}udel.edu
BACKGROUND: Loss of the transmembrane mucin, Muc-1, is a molecular correlate of the acquisition of uterine receptivity to embryo adhesion in most species examined. In macaques, two distinct adhesion events occur at opposite sides of the uterus. Attachment to the secondary site is delayed relative to the primary site. The aim was to determine if Muc-1 is removed at secondary sites prior to trophoblast attachment. METHODS: We examined Muc-1 expression in the uteri of cynomolgus macaque and baboon during early implantation by immunocytochemistry. RESULTS: Luminal epithelia were devoid of Muc-1 at all stages examined at both primary and secondary adhesion sites. Loss of Muc-1 in luminal epithelia was found to be maternally determined, accompanied membrane transformation in both macaque and baboon, and at secondary implantation sites, preceded trophoblast attachment. In contrast, glandular epithelia in pregnant macaques exhibited a temporal and compartmentalized gradient of Muc-1 loss confined to the implantation sites. Glandular epithelia in the pregnant baboon uterus were uniformly negative for Muc-1. CONCLUSIONS: Restriction of the Muc-1 loss in glandular epithelia to conceptual cycles may reflect the fundamental distinctions among epithelia of the various uterine compartments and the differential modulation of Muc-1 that occurs within these compartments in conceptual and non-conceptual cycles.
Key words: endometrium/implantation/Muc-1/primate/receptivity
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