Skip Navigation


Hum. Reprod. Advance Access originally published online on April 28, 2005
Human Reproduction 2005 20(6):1516-1520; doi:10.1093/humrep/deh832
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/6/1516    most recent
deh832v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Prapas, N.
Right arrow Articles by Makedos, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prapas, N.
Right arrow Articles by Makedos, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

GnRH agonist versus GnRH antagonist in oocyte donation cycles: a prospective randomized study

N. Prapas1,2, Y. Prapas1,2,4, Y. Panagiotidis2, S. Prapa2, P. Vanderzwalmen2,3, R. Schoysman3 and G. Makedos1

1 4th Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, 2 Iakentro Fertility Center, Thessaloniki, Greece and 3 SIMAF, Van Helmont Hospital, Vilvoorde, Belgium

4 To whom correspondence should be addressed. Email: iakentro{at}otenet.gr

BACKGROUND: The specific role of LH in folliculogenesis and oocyte maturation is unclear. GnRH antagonists, when administered in the late follicular phase, induce a sharp decrease in serum LH which may be detrimental for IVF outcome. This study was performed to evaluate whether the replacement of GnRH agonist (triptorelin) by a GnRH antagonist (ganirelix; NV Organon) in oocyte donation cycles has any impact on pregnancy and implantation rates. METHODS: A total of 148 donor IVF cycles was randomly assigned to use either a GnRH antagonist daily administered from the 8th day of stimulation (group I) or a GnRH agonist long protocol (group II) for the ovarian stimulation of their donors. The primary endpoints were the pregnancy and the implantation rates. RESULTS: The clinical pregnancy rate per transfer (39.72%, 29/73 versus 41.33%, 31/75) based on transvaginal scan findings at 7 weeks of gestation, the implantation rate (23.9 versus 25.4%) and the first trimester abortion rate (10.34 versus 12.90%) were similar in the two groups. CONCLUSION: In oocyte donation cycles the replacement of GnRH agonist by a GnRH antagonist appears to have no impact on the pregnancy and implantation rates when its administration starts on day 8 of stimulation.

Key words: GnRH agonist/GnRH antagonist/IVF/oocyte donor/ovarian stimulation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. Weghofer, S. Munne, W. Brannath, S. Chen, G. Tomkin, N. Cekleniak, M. Garrisi, D. Barad, J. Cohen, and N. Gleicher
The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation
Hum. Reprod., March 1, 2008; 23(3): 499 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.A. Huirne, R. Homburg, and C.B. Lambalk
Are GnRH antagonists comparable to agonists for use in IVF?
Hum. Reprod., November 1, 2007; 22(11): 2805 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H.-C. Ruan, X.-M. Zhu, Q. Luo, A.-X. Liu, Y.-L. Qian, C.-Y. Zhou, F. Jin, H.-F. Huang, and J.-Z. Sheng
Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice
Hum. Reprod., October 1, 2006; 21(10): 2521 - 2529.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Bodri, V. Vernaeve, J.J. Guillen, R. Vidal, F. Figueras, and O. Coll
Comparison between a GnRH antagonist and a GnRH agonist flare-up protocol in oocyte donors: a randomized clinical trial
Hum. Reprod., September 1, 2006; 21(9): 2246 - 2251.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.