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Hum. Reprod. Advance Access originally published online on March 24, 2005
Human Reproduction 2005 20(7):1887-1896; doi:10.1093/humrep/deh847
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

The choice and outcome of the fertility treatment of 38 couples in whom the male partner has a Yq microdeletion

Katrien Stouffs1,3, Willy Lissens1, Herman Tournaye2, André Van Steirteghem2 and Inge Liebaers1

1 Centre for Medical Genetics and 2 Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium

3 To whom correspondence should be addressed. Email: katrien.stouffs{at}az.vub.ac.be

BACKGROUND: Patients with Yq microdeletions may suffer from fertility problems. The purpose of this study was to assess the outcome of the fertility treatment of these patients. METHODS: For 38 patients with Yq microdeletions, data were collected about medical history, karyotype, testicular histopathology and the presence of spermatozoa in the ejaculate or testicular biopsies. RESULTS: Sixteen patients with an azoospermia factor region c (AZFc) deletion had at least one cycle with ICSI. The clinical pregnancy outcome was 22% per embryo transfer. Three babies have been born and two pregnancies are ongoing. Sex selection for female embryos in combination with ICSI in order to prevent the transmission of the fertility problems was discussed with 14 couples; eight were in favour of the selection. In addition, eight couples made the decision to use donor sperm because ICSI was impossible or objectionable and, in this group of patients, a total of nine babies were born. CONCLUSIONS: Despite the improvement of assisted reproductive technology, ICSI could be offered only to patients with an AZFc deletion. Insemination with donor sperm is a potential alternative for other patients.

Key words: infertility treatment/male infertility/microdeletions/Y chromosome


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