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Hum. Reprod. Advance Access originally published online on March 31, 2005
Human Reproduction 2005 20(7):2021-2024; doi:10.1093/humrep/deh846
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Comparison of hyaluronate/carboxymethylcellulose membrane and melatonin for prevention of adhesion formation in a rat model

Suzi Demirbag1,5, Salih Cetinkursun1, Umut Tasdemir2, Haluk Ozturk1, Mesut Pekcan3 and Narter Yesildaglar4

1 Department of Paediatric Surgery and Research Centre, 2 Lalahan Livestock Central Research Institute and Research Centre, 3 Department of Surgery and Research Centre and 4 Zübeyde Hn. Women's Hospital and Research Centre, Gülhane Military Medical Academy, Ankara, Turkey

5 To whom correspondence should be addressed at: GATA Cocuk Cerrahisi AD 06018 Etlik, Ankara, Turkey. Email: sdemirbag{at}gata.edu.tr

BACKGROUND: To investigate the effectiveness of melatonin in preventing post-operative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose membrane in a rat model. MATERIALS and METHODS: Following pilot studies, 35 rats were operated on in the full study. In 15 animals (group one), 10 standard lesions were inflicted in each uterine horn (total 30 horns) and melatonin was applied before closure of the abdomen. In the second group, 20 animals were operated on and one of the uterine horns (total 20 horns) with standard lesions was treated with hyaluronate/carboxymethylcellulose membrane and the other uterine horn served as a control. Second-look operations were performed 1 week later and adhesion scores were compared. RESULTS: The adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane were significantly lower than the scores of the controls (P<0.001). There was no statistically significant difference between the adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane (P>0.05). CONCLUSIONS: Both melatonin and hyaluronate/carboxymethylcellulose membrane were effective in prevention of adhesion formation in a rat uterine horn model.

Key words: adhesion formation/hyaluronate–carboxymethylcellulose membrane/melatonin/surgical barriers/rat uterine horn model


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