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Hum. Reprod. Advance Access originally published online on June 9, 2005
Human Reproduction 2005 20(8):2242-2246; doi:10.1093/humrep/dei031
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

ICSI for treatment of human immunodeficiency virus and hepatitis C virus-serodiscordant couples with infected male partner

Luca Mencaglia1,3, Patrizia Falcone1, Giuseppe Mario Lentini1, Sabina Consigli1, Manuela Pisoni1, Vincenzo Lofiego1, Rita Guidetti1, Paola Piomboni2 and Vincenzo De Leo2

1 Centro di Chirurgia Ambulatoriale SrL, Via Toselle 178, 50144, Florence and 2 Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico S. Maria alle Scotte, Siena, Italy

3 To whom correspondence should be addressed. Email: piomboni{at}unisi.it

BACKGROUND: Assisted reproductive technology with semen washing can offer a significant reduction in risk of sexual and vertical transmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) in serodiscordant couples with infected male partner. METHODS: Among couples coming to our centre for reproductive problems from January 2001 to December 2003, we selected 43 couples with seropositive male and seronegative female: 25 couples with HIV-seropositive males, 10 couples with HIV/hepatitis C virus (HCV)-seropositive males and eight couples with HCV-seropositive males. Sperm samples were washed and used for ICSI. RESULTS: Seventy-eight cycles of ICSI were performed. The mean fertilization rate was 70.34 ± 20.14% (mean ± SD). A mean number of 3.55 ± 1.11 (range: 1–5) embryos of good quality was transferred for each patient. We obtained 22 pregnancies (21 singletons and one twin), with a pregnancy rate per transfer of 28.2% and an implantation rate per transfer of 15.2%. The cumulative pregnancy rate was 51.2%. At follow-up, no seroconversion was detected in any patient. CONCLUSIONS: Our data suggest that sperm wash and ICSI could be useful for reducing the risk of HIV and/or HCV transmission in serodiscordant couples with infected male wishing to have a child, irrespective of their fertility status.

Key words: HCV/HIV/ICSI/seropositive male/sperm wash


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