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Hum. Reprod. Advance Access originally published online on May 12, 2005
Human Reproduction 2005 20(9):2550-2551; doi:10.1093/humrep/dei092
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

‘Vanishing embryo syndrome’ in IVF/ICSI

Dorte Hvidtjørn1,5, Jakob Grove1, Diana Schendel1,2, Michael Væth3, Erik Ernst4, Lene Nielsen1 and Poul Thorsen1

1 NANEA, Department of Epidemiology, Institute of Public Health, University of Aarhus, Paludan-Müllers Vej 17, DK-8000 Aarhus C, Denmark, 2 Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, USA, 3 Department of Biostatistics, Institute of Public Health, University of Aarhus and 4 Fertility Section, Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark

5 To whom correspondence should be addressed. Email: dh{at}soci.au.dk

BACKGROUND: In a Danish population-based cohort study assessing the risk of cerebral palsy in children born after IVF, we made some interesting observations regarding ‘vanishing co-embryos’. METHODS and RESULTS: All live-born children born in Denmark from 1 January 1995 to 31 December 2000 were included in this analysis. The children conceived by IVF/ICSI (9444) were identified through the IVF Register, the children conceived without IVF/ICSI (395 025) were identified through The Danish Medical Birth Register. Main outcome measure was the incidence of cerebral palsy. Within the IVF/ICSI children we found indications of an increased risk of cerebral palsy in those children resulting from pregnancies, where the number of embryos transferred was higher than the number of children born. CONCLUSIONS: The association between vanishing embryo syndrome and incidence of cerebral palsy following IVF requires further investigation in larger, adequately powered, studies.

Key words: cerebral palsy/IVF/vanishing embryo syndrome


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