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Hum. Reprod. Advance Access originally published online on May 19, 2005
Human Reproduction 2005 20(9):2573-2578; doi:10.1093/humrep/dei061
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Quality specifications for seminal parameters based on the state of the art

J.A. Castilla1,2,7, J. Morancho-Zaragoza3, J. Aguilar2,4, R. Prats-Gimenez3, M.C. Gonzalvo2,5, E. Fernández-Pardo3, C. Álvarez2,6, R. Calafell3 and L. Martinez1

1 Unidad de Reproducción, Hospital Virgen de las Nieves, E-18014, Granada, 2 Programa de Control de Calidad Externo de Análisis de Semen, Asociación para el Estudio de la Biología de la Reproducción (ASEBIR), 3 Programa de Supervisión Externa de la Calidad, Asociación Española de Farmacéuticos Analistas, AEFA, Madrid, 4 Unidad de Reproducción, Clínica Avicena, Jaén, 5 CEIFER, Granada and 6 Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

7 To whom correspondence should be addressed. Email: josea.castilla.sspa{at}juntadeandalucia.es

BACKGROUND: The aim of this study was to calculate the analytical goal for seminal parameters based on the state of the art, and then to compare these specifications with those previously obtained by our group based on biological variation. METHODS: All data used for analysis were derived from the Spanish programme of external quality control on semen analysis. Over 90 laboratories participated from 1999 to 2003. Using graphs of the state of the art, we also determined the numbers of laboratories that achieved quality specifications. RESULTS: The total allowable error calculated using state of the art graphs is similar to that calculated using biological variation for concentration and total motility. However, it is much higher for morphology and rapidly progressive motility. Over 80% of the laboratories achieved the minimum quality specification based on biological variation for concentration, total and progressive motility. However, only ~30% of the laboratories achieved the minimum quality specification based on biological variation for morphology and rapidly progressive motility. CONCLUSIONS: The study enabled us to identify the state of the art of analytical performance for seminal parameters, and revealed the difficulty inherent in meeting the quality specifications based on biological variation.

Key words: analytical goals/quality control/semen/state of the art


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