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Hum. Reprod. Advance Access originally published online on June 9, 2005
Human Reproduction 2005 20(9):2639-2647; doi:10.1093/humrep/dei105
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Effect on expression of RT1-A and RT1-DM molecules of treatment with interferon-{gamma} at the maternal—fetal interface of pregnant rats

Quan-Hong Sun1, Jing-Pian Peng1,2, Hong-Fei Xia1, Ying Yang1 and Mei-Ling Liu1

1 State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China

2 To whom correspondence should be addressed. Email: pengjp{at}ioz.ac.cn

BACKGROUND: Recent studies suggest a role for interferon-{gamma} (IFN-{gamma}) in the pregnancy process. METHODS: The expression of non-classical class II major histocompatibility complex (RT1-DM) antigens and classical class I major histocompatibility complex (RT1-A) antigens induced by IFN-{gamma} was examined by reverse transcription–PCR, western blotting and immunohistochemistry. RESULTS: IFN-{gamma} treatment increased expression of RT1-DM and RT1-A during early pregnancy and decreased them during mid pregnancy at the maternal–fetal interface. In late pregnancy, expression of RT1-A decreased in placenta and increased in uterus, and RT1-DM increased in both placenta and uterus with IFN-{gamma} treatment compared with untreated controls. Immunohistochemical studies suggested that in early pregnancy, RT1-DM protein mainly localized to uterine luminal epithelium and glandular epithelium, and RT1-A mainly localized to decidual blood vessels and decidua basalis. During mid and late pregnancy, RT1-A mainly localized in decidual blood vessels and spongiotrophoblast cells of the junction zone. RT1-DM mainly localized in blood vessels and the labyrinthine zone during mid and late gestation. CONCLUSIONS: RT1-A and RT1-DM can both be expressed at the maternal–fetal interface during normal pregnancy. Their localizaion changed according to the period of pregnancy. IFN-{gamma} can modulate the expression of these two molecules during the whole pregnancy.

Key words: IFN-{gamma}/placenta/RT1-A/RT1-DM/uterus


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