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Hum. Reprod. Advance Access originally published online on September 9, 2005
Human Reproduction 2006 21(1):36-45; doi:10.1093/humrep/dei295
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Contractile reactivity of human myometrium in isolated non-pregnant uteri

O.N. Richter1,2,3, C. Bartz1, J. Dowaji1, M. Kupka2, J. Reinsberg2, U. Ulrich2 and W. Rath1

1 Department of Obstetrics and Gynaecology, University of Aachen School of Medicine, Aachen and 2 Department of Obstetrics and Gynaecology, University of Bonn School of Medicine, Bonn, Germany

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, University of Aachen School of Medicine, Pauwelsstraße 30, D-52057 Aachen, Germany. E-mail: orichter{at}ukaachen.de

BACKGROUND: Perfusion of the isolated uterus has been shown to be a feasible experimental system for studies of the human endometrium and myometrium. Utilizing our established experimental perfusion model we perfused 20 uteri for 27 h and investigated the contractile reactivity of the myometrium in response to 17{beta}-estradiol (E2) and oxytocin (OT). METHODS: Uteri of group A (n = 4) were stimulated with OT; group B (n = 4) was treated continuously with E2; group C (n = 4) received both E2 and OT for 27 h; group D (n = 4) was perfused for 27 h with E2 with the addition of OT for the last 3 h of the experiment; group E (n = 4) as control group remained without any treatment. The pressure and duration of uterine contractions were recorded during the entire perfusion period using intramural and endoluminal pressure catheters. RESULTS: Compared to the other treatment groups and controls, the most effective myometrial activity was achieved in group D during the OT stimulation period. No relevant myometrial activity was detected in the control group. CONCLUSIONS: Continuous E2 treatment, with the addition of OT for the last 3 h of the 27 h perfusion period, led to the most pronounced uterotonic effects in the presented experimental condition.

Key words: human non-pregnant uterus/myometrial contractility/oxytocin/perfusion of the isolated uterus


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