Hum. Reprod. Advance Access originally published online on August 3, 2006
Human Reproduction 2006 21(11):2935-2940; doi:10.1093/humrep/del277
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ART outcome in HIV-infected patients
1 Department of Obstetrics and Gynaecology and 2 Department of Internal Medicine, Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Buxelles, Brussels, Belgium
3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, CHU Saint-Pierre, Université Libre de Buxelles, 322 rue Haute, 1000 Brussels, Belgium. E-mail: annick_delvigne{at}stpierre-bru.be
BACKGROUND: To assess assisted reproductive technique (ART) outcome in couples affected by human immunodeficiency virus (HIV). METHODS: Intrauterine insemination (IUI), IVF and ICSI were performed in 85 couples affected by HIV between January 2000 and June 2005. RESULTS: In 33 of the 85 couples, women were HIV positive—the clinical pregnancy rate (CPR) and cancellation rate (CR) after 34 IUI cycles were, respectively, 25 and 18%. The CPR after 26 IVF and 30 ICSI cycles were, respectively, 37.5 and 18.8% with CRs of 38.5 and 46.7%, respectively. In 38 couples, men were infected—the CPR and CR after 85 IUI cycles were, respectively, 14.7 and 20%; 62 ICSI cycles were performed leading to CPR of 23.4% with a CR of 25%. In 14 couples, the two partners were infected: none of the four IUI cycles carried out was successful (CR, 20%); the CPR and CR after 35 ICSI cycles were, respectively, 12.5% with 31%. All children born had a negative HIV test. CONCLUSION: In couples affected by HIV, an acceptable pregnancy rate was obtained. The worst results were obtained when both partners were infected. The CR was elevated among HIV-infected couples.
Key words: ART/HIV/ICSI/IUI/IVF
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