Hum. Reprod. Advance Access originally published online on August 21, 2006
Human Reproduction 2006 21(12):3103-3107; doi:10.1093/humrep/del291
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Serum anti-Mullerian hormone throughout the human menstrual cycle
1 Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena and 2 Department of Medicine and Pharmacology, University of Messina, Messina, Italy
3 To whom correspondence should be addressed at: Mother-Infant Department, Institute of Obstetrics and Gynecology, Policlinico di Modena, University of Modena and Reggio Emilia, Largo del Pozzo, 41100 Modena, Italy. E-mail: antlamarca{at}libero.it
BACKGROUND: The anti-Mullerian hormone (AMH) is a member of the transforming growth factor (TGF) superfamily. In women, AMH serum levels can be almost undetectable at birth, with a subtle increase noted after puberty. Data are lacking with regard to menstrual cycle day-to-day fluctuations. This longitudinal study was designed to investigate the pattern of secretion of AMH throughout the menstrual cycle in regularly cycling women. METHODS: Twelve healthy female subjects aged 18–24 years participated in this study. Blood samples were taken every other day throughout one menstrual cycle. Serum FSH, LH, estradiol (E2), progesterone, inhibin B and AMH levels were assayed by double-antibody radioimmunoassay using commercial kits. RESULTS: Serum AMH in the first days of the menstrual cycle (days –14 to –12) was 3.8 ± 1.2 ng/ml (mean ± SD). No significant changes were observed in serum AMH levels throughout the menstrual cycle. The highest value was 3.9 ± 1.3 ng/ml at day –12 and the lowest value was 3.4 ± 1.1 ng/ml at day 14, and the difference was not significant. CONCLUSION: In this study, we demonstrated that serum AMH levels do not change significantly throughout the menstrual cycle. Hence, AMH exhibits a relatively stable expression during the menstrual cycle, making it an attractive determinant of ovarian activity.
Key words: anti-Mullerian hormone/gonadotrophins/inhibin B/physiological menstrual cycle/sex steroids
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