Skip Navigation


Hum. Reprod. Advance Access originally published online on August 17, 2006
Human Reproduction 2006 21(12):3193-3198; doi:10.1093/humrep/del314
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/12/3193    most recent
del314v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Moradkhani, K.
Right arrow Articles by Pellestor, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moradkhani, K.
Right arrow Articles by Pellestor, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Rare Robertsonian translocations and meiotic behaviour: sperm FISH analysis of t(13;15) and t(14;15) translocations: A Case Report

K. Moradkhani1,2,3, J. Puechberty1,2, S. Bhatt1, J. Lespinasse4, P. Vago5, G. Lefort2, P. Sarda2, S. Hamamah6 and F. Pellestor1,7

1 Institute of Human Genetics, CNRS 2 Department of Medical Genetics, CHU Montpellier, France 3 Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran 4 Laboratory of Cytogenetics, CHU Chambery 5 Laboratory of Cytogenetics, CHU Clermont-Ferrand and 6 Laboratory of Biology of the Reproduction, CHU Montpellier, France

7 To whom correspondence should be addressed at: CNRS UPR 1142, Institute of Human Genetics, 141 Rue de la Cardonille, F-34396 Montpellier Cedex 5, France. E-mail: franck.pellestor{at}igh.cnrs.fr

t(13;15) and t(14;15) are two rare Robertsonian translocations. Meiotic segregation was studied in four males heterozygous for the rare Robertsonian translocations t(13;15) and t(14;15). Both locus-specific probes (LSPs) and whole chromosome painting (WCP) probes, specific to chromosomes 13, 14 and 15, were used in this study. The number of spermatozoa scored for each carrier ranged from 891 to 5000. The frequencies of normal and balanced sperm resulting from the alternate mode of segregation ranged from 77.6 to 92.8%, confirming the prevalence of alternate segregation over other segregation modes in all Robertsonian translocations. The incidences of unbalanced complements ranged from 6.7 to 20.4%, with a significant excess of disomy rates over the complementary frequencies of nullisomy. This variability might reflect differences in the location of breakpoints in translocated chromosomes, leading to the variable production of unbalanced gametes and the variable alterations of semen parameters in Robertsonian translocation carriers.

Key words: FISH/meiotic segregation/Robertsonian translocation/sperm


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. Pinton, A. Calgaro, N. Bonnet, S. Ferchaud, S. Billoux, A.M. Dudez, N. Mary, K. Massip, A. Bonnet-Garnier, M. Yerle, et al.
Influence of sex on the meiotic segregation of a t(13;17) Robertsonian translocation: a case study in the pig
Hum. Reprod., August 1, 2009; 24(8): 2034 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
R.H. Martin
Cytogenetic determinants of male fertility
Hum. Reprod. Update, June 4, 2008; (2008) dmn017v1.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.