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Hum. Reprod. Advance Access originally published online on October 27, 2005
Human Reproduction 2006 21(2):447-450; doi:10.1093/humrep/dei327
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Comparison of serum FSH and Inhibin B levels between adult male dizygotic and monozygotic twins

Alastair Sutcliffe1,10, Helen A. Spoudeas5, Devaki Nair2, Pierre Bouloux3, Tim Oliver6, Philip Sambrook8, Wendy Bannister4, Cornelis B. Lambalk9 and Tim Spector7

1 Department of Child Health, 2 Department of Chemical Pathology, 3 Reader in Endocrinology, 4 Department of Primary Care and Population Sciences, Royal Free and University College Medical School, NW3 2PF, 5 Consultant Paediatric Endocrinologist, University College and Great Ormond Street Hospitals, 6 St Bartholomew’s and The Royal London Hospital, London, and 7 Twin Research and Genetic Epidemiology Unit, St Thomas’s Hospital, London, UK, 8 Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia 2065 and 9 Division of Reproductive Medicine, Vrije Universiteit Medical Centre (VUMC), Amsterdam, The Netherlands

10 To whom correspondence should be addressed. E-mail: a.sutcliffe{at}medsch.ucl.ac.uk

BACKGROUND: FSH hypersecretion occurs in mothers of dizygotic (DZ) twins. Twinning is inherited via both sexes and transmitted through the female. FSH hypersecretion may thus occur in male DZ twins. METHODS: We assayed FSH and its counter-regulatory hormone, Inhibin B, in 108 adult male DZ and 100 monozygotic (MZ) twins (as controls) and compared our results to published norms. RESULTS: Inhibin B was elevated and higher in DZ compared with MZ twins with similar FSH. CONCLUSION: The normal FSH: Inhibin B endocrine feedback axis is different in adult male DZ twins. This contributes to the theory that the answer to human DZ twinning lies in the actions of FSH and Inhibin, and in their mutual interaction.

Key words: FSH hypersecretion/inhibin B/twins


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