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Hum. Reprod. Advance Access originally published online on October 27, 2005
Human Reproduction 2006 21(3):728-734; doi:10.1093/humrep/dei369
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Antiphospholipid antibodies in serum and follicular fluid—is there a correlation with IVF implantation failure?

K.L. Buckingham1,2,4, P.R. Stone1, J.F. Smith3 and L.W. Chamley1,2

1 Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1001, 2 Fertility Plus, Greenlane Clinical Centre, Private Bag 92189, Auckland 1003 and 3 Reproductive Technologies Group, AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 2001, New Zealand

4 To whom correspondence should be addressed. E-mail: karen{at}onlinecom.co.nz

BACKGROUND: Antiphospholipid antibodies (aPLs) are associated with infertility, but the mechanism underlying this statistical association is currently obscure. We aimed to investigate the finding that aPLs are concentrated in follicular fluid and to establish if this is associated with a poorer outcome from IVF. METHODS AND RESULTS: In 19.2% of 99 women undergoing IVF, at least one aPL was detected in their serum and/or follicular fluids, but the antibody levels in follicular fluid were not higher than in serum. Women with aPLs had a lower implantation rate (14%) than women without these antibodies (24.1%), but this difference was not significant (P = 0.127). There was also a non-significant reduction in the live birth rate for women with aPLs. In a parallel investigation, 10 sheep immunized with beta2 glycoprotein I (beta2GPI) or irrelevant control antigens showed strong immune responses, but there were no significant differences between the levels of antibodies in the follicular fluid or serum from beta2GPI or control immunized sheep. CONCLUSION: aPLs do not appear to be selectively concentrated in follicular fluids and, when present, do not adversely affect the reproductive outcome of women undergoing IVF.

Key words: anticardiolipin/antiphosphatidylserine/antiphospholipid antibodies/beta2 glycoprotein I/IVF


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