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Hum. Reprod. Advance Access originally published online on November 3, 2005
Human Reproduction 2006 21(3):735-737; doi:10.1093/humrep/dei379
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Blood chimerism in monochorionic twins conceived by induced ovulation: Case report

Rika Aoki1,3, Yoko Honma1,4, Yukari Yada1, Mariko Y. Momoi1 and Sadahiko Iwamoto2

1 Department of Pediatrics,2 Department of Regal Medicine, Jichi Medical School, 3311-1Yakushiji, Minamikawachimachi, Tochigi, Japan 329-0498,3 Present address: Department of Pediatrics, Odawara Municipal Hospital, 46 Kuno Odawara City, Kanagawa, Japan 250-8558

4 To whom correspondence should be addressed. E-mail: yokohoma{at}jichi.ac.jp

A case of monochorionic twin boys delivered at 34 weeks of gestation following induced ovulation with clomiphene is described. One twin was typed as blood group AB and the other as B. Flow cytometry showed blood group chimerism. DNA polymorphism analysis of peripheral lymphocytes and hair root cells showed that the chimerism was confined to the blood cells and they were dizygotic.

Key words: blood chimerism/dizygotic twins/induced ovulation/monochorionic placenta


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C. E. Boklage
Traces of embryogenesis are the same in monozygotic and dizygotic twins: not compatible with double ovulation
Hum. Reprod., June 1, 2009; 24(6): 1255 - 1266.
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