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Hum. Reprod. Advance Access originally published online on November 25, 2005
Human Reproduction 2006 21(3):738-744; doi:10.1093/humrep/dei403
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study*

Lourdes Muriel1, Marcos Meseguer2,3, Jose Luis Fernández1, Juan Alvarez4, José Remohí1, Antonio Pellicer1 and Nicolás Garrido2,3,5

1 Sección de Genetica y Unidad de Investigación, Hospital ‘Teresa Herrera’, Complejo Hospitalario Juan Canalejo, A Coruña, 2 Instituto Universitario IVI, Valencia, 3 FIVI, (Fundación IVI) Valencia, Spain and 4 Centro de Infertilidad Masculina ANDROGEN, La Coruña and Harvard Medical School, Boston, USA

5 To whom correspondence should be addressed at: Instituto Valenciano de Infertilidad, Andrology Laboratory and Semen Bank, Plaza de la Policía Local 3, Valencia 46015, Spain. E-mail: nicolas.garrido{at}ivi.es

BACKGROUND: Sperm DNA integrity has been used as a new marker of sperm quality in the prediction of pregnancy. Nevertheless, no previous study has been performed by analysing the same samples that were employed in assisted reproduction. The main objective of this work was to correlate sperm chromatin dispersion (SCD), measured by the SCD test, with semen parameters and pregnancy outcome in intrauterine insemination (IUI). METHODS: A total of 100 semen samples obtained from males of couples undergoing IUI were analysed by the SCD test before and after swim-up, and the results were correlated with semen parameters and pregnancy outcome. RESULTS: SCD was negatively correlated with sperm motility in both ejaculated and processed semen. Sperm recovered by swim-up did not show a significant improvement in DNA integrity. No correlation was found between SCD and pregnancy outcome in IUI. CONCLUSIONS: DNA dispersion, as measured by the SCD test, is not correlated with pregnancy outcome in IUI.

Key words: DNA/intrauterine insemination/sperm/sperm chromatin dispersion test

* This work was presented at the 21st Annual Meeting of the ESHRE in Copenhagen (Denmark).


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[Abstract] [Full Text] [PDF]


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