Skip Navigation


Hum. Reprod. Advance Access originally published online on November 10, 2005
Human Reproduction 2006 21(3):753-754; doi:10.1093/humrep/dei380
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/3/753    most recent
dei380v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Writzl, K.
Right arrow Articles by Peterlin, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Writzl, K.
Right arrow Articles by Peterlin, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Preliminary analysis of AZFb region duplication by quantitative real-time PCR

K. Writzl1, B. Zorn2 and B. Peterlin1,3

1 Division of Medical Genetics and 2 Andrology Centre, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slajmerjeva 3, Ljubljana 1000, Slovenia

3 To whom correspondence should be addressed. E-mail: borut.peterlin{at}guest.arnes.si

BACKGROUND: Deletions of the AZFb region on the long arm of the human Y chromosome cause male infertility. However, the reciprocal products of these deletion events, AZFb duplications, have not been reported to date. Furthermore, it is not known whether potential AZFb duplications represent a risk factor for spermatogenic failure. METHODS: A total of 150 patients with male idiopathic subfertility (79 non-obstructive azoospermics and 71 oligozoospermics) and 150 fertile men were analysed for deletion/duplication of the sY125 locus and of the JARID1D gene using real-time PCR. RESULTS: Three azoospermic men had deletion of the sY125 locus and of the JARID1D gene. No duplication was detected. CONCLUSIONS: In our limited sample, AZFb duplications do not appear to be associated with male infertility.

Key words: AZFb/deletions/duplications/male infertility/real-time PCR


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.