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Hum. Reprod. Advance Access originally published online on December 22, 2005
Human Reproduction 2006 21(4):930-935; doi:10.1093/humrep/dei431
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease?

Semra Topcu1,4, Mustafa Caliskan1, Emel Ebru Ozcimen2, Derya Tok1, Ayla Uckuyu2, Dogan Erdogan1, Hakan Gullu1, Aylin Yildirir3, Hulusi Zeyneloglu2 and Haldun Muderrisoglu3

1 Cardiology Department and 2 Obstetrics & Gynecology Department, Konya Teaching and Medical Research Center, Baskent University, Konya and 3 Cardiology Department, Baskent University Faculty of Medicine, Ankara, Turkey

4 To whom correspondence should be addressed at: Cardiology Department Hoca Cihan mah, Konya Teaching and Medical Research Center, Saray Cad, No. 1, Selcuklu, Konya, Turkey. E-mail: semratopcu2003{at}yahoo.com

BACKGROUND: It is thought that women with polycystic ovary syndrome (PCOS) are at increased risk of developing cardiovascular diseases. METHODS: In this study, we used transthoracic echocardiography to measure coronary flow reserve (CFR) in 28 women with PCOS and in 26 healthy women. RESULTS: The PCOS and the control groups were similar in terms of age (27.1 ± 4.5 versus 28.8 ± 4.4 years) and BMI (26.6 ± 5.7 versus 24.7 ± 4.4 kg/m2). Fasting insulin levels and homeostasis model assessment insulin resistance index were higher in the PCOS group. LH, the LH/FSH ratio, total testosterone, free testosterone and androstenedione were higher in the PCOS group. FSH, estradiol, prolactin, progesterone, cholesterol, triglyceride and high-sensitive C-reactive protein were similar between the two groups, but homocysteine levels were higher in the PCOS group. Baseline diastolic peak f low velocity (DPFV) (25.0 ± 4.6 versus 23.3 ± 2.7 cm/s, P > 0.05), hyperaemic DPFV (71.2 ± 12.8 versus 73.0 ± 12.9 cm/s, P > 0.05) and CFR (2.8 ± 0.8 versus 3.2 ± 0.8 cm/s, P > 0.05) of the left anterior descending coronary artery were similar between the two groups. CONCLUSION: We conclude that in young women with PCOS and without cardiovascular risk factors, CFR is preserved.

Key words: coronary artery disease/coronary flow reserve/polycystic ovary syndrome


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