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Hum. Reprod. Advance Access originally published online on February 13, 2006
Human Reproduction 2006 21(5):1227-1231; doi:10.1093/humrep/dei478
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Routine use of hysterosalpingography prior to laparoscopy in the fertility workup: a multicentre randomized controlled trial

D.A.M. Perquin1,4, P.J. Dörr1, A.J.M. de Craen2 and F.M. Helmerhorst3

1 Department of Obstetrics and Gynaecology, Medical Centre Haaglanden, The Hague, 2 Department of Gerontology and Geriatrics and 3 Department of Gynaecology, Division of Reproductive Medicine, Leiden University Medical Centre, Leiden, The Netherlands

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Medical Centre Haaglanden, PO Box 432, 2501 CK, The Hague, The Netherlands. E-mail: dperquin{at}knoware.nl

BACKGROUND: A multicentre randomized controlled trial with or without hysterosalpingography (HSG) was conducted to assess the usefulness of HSG as a routine investigation in the fertility workup prior to laparoscopy and dye. METHODS: From 1 April 1997 to 1 April 2002, subfertile women were allocated by a computer–based 1 : 1 ratio randomization procedure, either for an HSG followed by laparoscopy and dye (the intervention group) of for laparoscopy and dye only (the control group) as a part of their fertility workup. Cumulative pregnancy rate (CPR) within 18 months after randomization was the primary outcome of interest. RESULTS: 344 women were randomized to the intervention group (n = 169) and the control group (n = 175). There was no significant difference in CPR at 18 months in the intervention group (49.1%) [95% confidence interval (CI) 41.6 to 56.6] and the control group (50.3%) (95% CI 42.8 to 57.8), a difference of –1.2% (95% CI –11.8% to 9.5%). CONCLUSION: The routine use of HSG at an early stage in the fertility workup prior to laparoscopy and dye does not influence CPR, compared with the routine use of laparoscopy and dye without HSG.

Key words: hysterosalpingography/laparoscopy and dye/pregnancy rate/randomized controlled trial


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