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Hum. Reprod. Advance Access originally published online on February 3, 2006
Human Reproduction 2006 21(6):1368-1379; doi:10.1093/humrep/del010
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Reducing ischaemic damage in rodent ovarian xenografts transplanted into granulation tissue

Tomer Israely1,3, Nava Nevo1, Alon Harmelin2, Michal Neeman1 and Alex Tsafriri1

1 Department of Biological Regulation and 2 Department of Veterinary Resources, The Weizmann Institute of Science, Rehovot, Israel

3 To whom correspondence should be addressed at: Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: alex.tsafriri{at}weizmann.ac.il

BACKGROUND: Anti-cancer therapies frequently lead to ovarian damage and impaired fertility. To preserve fertility, cryopreservation and subsequent transplantation of the ovaries have been suggested. One of the challenges in ovarian graft transplantation is overcoming the initial ischaemic damage that depletes a significant fraction of the oocyte pool. METHODS AND RESULTS: Follicular survival in ovarian grafts was examined by magnetic resonance imaging (MRI) and fluorescence microscopy in a model system in which rat ovaries were transplanted into nude mice. Transplantation into angiogenic granulation tissue created during wound healing shortened the ischaemic period by 24 h and significantly increased the pool of healthy primordial follicles and the perfused area of the transplanted grafts. Functional blood vessels were detected within the grafts as early as 2 days after transplantation. Gain of function was demonstrated both by growth of the grafts and by the hormonal influence on the host uteri. CONCLUSION: Implantation of ovarian grafts into an angiogenic granulation tissue improved graft vascularization and follicular survival. This procedure/treatment may be used for reducing the ischaemic damage in ovarian transplants, thus prolonging graft functionality and increasing the yield of oocytes that can be easily recovered for fertilization.

Key words: animal model/granulation tissue/ischaemia–reperfusion injury/oocyte pool/ovarian transplantation


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