Skip Navigation


Hum. Reprod. Advance Access originally published online on February 3, 2006
Human Reproduction 2006 21(6):1521-1524; doi:10.1093/humrep/del001
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/6/1521    most recent
del001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Greco, E.
Right arrow Articles by Tesarik, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greco, E.
Right arrow Articles by Tesarik, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Limiting the number of injected oocytes to three impairs ICSI outcomes in patients with nonobstructive azoospermia

E. Greco1, F. Ubaldi1, L. Rienzi1, M. Iacobelli1, S. Ferrero1, G. Minasi1, S. Romano1, C. Litwicka1 and Jan Tesarik2,3

1 Centre for Reproductive Medicine, European Hospital, Rome, Italy and 2 MAR&Gen, Molecular Assisted Reproduction & Genetics, Gracia, Granada, Spain

3 To whom correspondence should be addressed at: MAR&Gen Calle Rey Abu Said, 19 Urb. Alcázer del Genil 18006, Granada, Spain. E-mail: cmendoza{at}ugr.es

BACKGROUND: Since March 2004, only a maximum of three oocytes were allowed to be subjected to ICSI at one time in Italy. A previous study failed to show an impact of this restriction on fresh embryo transfer outcomes. The objective of this study was to compare ICSI outcomes before and after this restriction in patients with nonobstructive azoospermia. METHODS: Patients underwent testicular sperm extraction followed by ICSI. Biological (fertilization rate and the percentage of good-morphology zygotes and embryos) and clinical (clinical pregnancy and implantation rates) outcomes of the last 100 ICSI attempts before the restriction and outcomes of the first 100 ICSI attempts after the restriction were compared. RESULTS: Despite comparable fertilization rates (58.8% versus 59.2%; P > 0.05), there was a significant decrease in the percentage of good-morphology zygotes (41.1% versus 88.4%; P < 0.05) and embryos (36.7% versus 74.0%; P < 0.05) in the cohort of embryos transferred, clinical pregnancy rate (22.7% versus 42.4%; P < 0.05) and cumulative pregnancy rate from fresh and frozen embryo transfers (22.7% versus 53.5%; P < 0.05) after the restriction. CONCLUSION: The oocyte number restriction reduces dramatically the chance of achieving a clinical pregnancy in cases of nonobstructive azoospermia.

Key words: clinical outcomes/ICSI/nonobstructive azoospermia/oocyte number/testicular sperm


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
R. Ciriminna, M.L. Papale, P.G. Artini, M. Costa, L. De Santis, L. Gandini, L. Parmegiani, G. Ragni, A. Revelli, L. Rienzi, et al.
Impact of Italian legislation regulating assisted reproduction techniques on ICSI outcomes in severe male factor infertility: a multicentric survey
Hum. Reprod., September 1, 2007; 22(9): 2481 - 2487.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.