Hum. Reprod. Advance Access originally published online on March 29, 2006
Human Reproduction 2006 21(7):1798-1804; doi:10.1093/humrep/del085
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO Group II anovulatory infertility: a randomized controlled study
1 Center for Reproductive Medicine of the Vrije Universiteit Brussel, Brussels, Belgium 2 Rigshospitalet, Fertility Clinic, Copenhagen, Denmark 3 Leeds General Infirmary, Department of Obstetrics & Gynaecology, Leeds, UK and 4 Ferring Pharmaceuticals A/S, Obstetrics & Gynaecology, Clinical Research & Development, Copenhagen, Denmark
5 To whom correspondence should be addressed: Center for Reproductive Medicine of the Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail: peter.platteau{at}az.vub.ac.be
BACKGROUND: The contribution of the LH activity in menotrophin preparations for ovulation induction has been investigated in small trials conducted versus FSH preparations. The objective of this study was to demonstrate non-inferiority of highly purified urinary menotrophin (HP-HMG) versus recombinant FSH (rFSH) with respect to the primary outcome measure, ovulation rate. METHODS: This was a randomized, open-label, assessor-blind, multinational study. Women with anovulatory infertility WHO Group II and resistant to clomiphene citrate were randomized (computer-generated list) to stimulation with HP-HMG (n = 91) or rFSH (n = 93) using a low-dose step-up protocol. RESULTS: The ovulation rate was 85.7% with HP-HMG and 85.5% with rFSH (per-protocol population), and non-inferiority was demonstrated. Significantly fewer intermediate-sized follicles were observed in the HP-HMG group (P < 0.05). The singleton live birth rate was comparable between the two groups. The frequency of ovarian hyperstimulation syndrome and/or cancellation due to excessive response was 2.2% with HP-HMG and 9.8% with rFSH (P = 0.058). CONCLUSIONS: Stimulation with HP-HMG is associated with ovulation rates at least as good as a rFSH in anovulatory WHO Group II women. LH activity modifies follicular development so that fewer intermediate-sized follicles develop. This could have a positive impact on the safety of ovulation induction protocols.
Key words: anovulation/highly purified menotrophin/ovulation induction/polycystic ovary syndrome/recombinant FSH
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Bosch, C. Vidal, E. Labarta, C. Simon, J. Remohi, and A. Pellicer Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study Hum. Reprod., June 25, 2008; (2008) den220v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nyboe Andersen, A. Balen, P. Platteau, P. Devroey, L. Helmgaard, J.-C. Arce, and for the Bravelle Ovulation Induction (BOI) Study G Predicting the FSH threshold dose in women with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate Hum. Reprod., June 1, 2008; 23(6): 1424 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Andersen, P. Devroey, and J.-C. Arce Reply: Comparing highly purified hMG and rFSH in patients undergoing IVF Hum. Reprod., June 1, 2007; 22(6): 1798 - 1800. [Full Text] [PDF]
|
|
|
|
|
|
J. Smitz, A.N. Andersen, P. Devroey, J.-C. Arce, and for the MERIT Group Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients Hum. Reprod., March 1, 2007; 22(3): 676 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Andersen, P. Devroey, J.-C. Arce, and for the MERIT Group Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial Hum. Reprod., December 1, 2006; 21(12): 3217 - 3227. [Abstract] [Full Text] [PDF]
|
|