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Hum. Reprod. Advance Access originally published online on May 26, 2006
Human Reproduction 2006 21(8):2033-2040; doi:10.1093/humrep/del094
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Acceptability of an injectable male contraceptive regimen of norethisterone enanthate and testosterone undecanoate for men

M.Cristina Meriggiola1,5, S. Cerpolini1, W.J. Bremner2, M.T. Mbizvo3, K.M. Vogelsong3, G. Martorana4 and G. Pelusi1

1 Obstetrics and Gynecology Unit, University of Bologna and S. Orsola Hospital, Bologna, Italy 2 Department of Medicine, University of Washington, Seattle, WA, USA 3 The UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland and 4 Clinic of Urology, University of Bologna and S. Orsola Hospital, Bologna, Italy

5 To whom correspondence should be addressed at: Clinic of Obstetrics and Gynecology, S. Orsola-Malpighi, Via Massarenti 13, 40138 Bologna, Italy. E-mail: cristina.meriggiola{at}unibo.it

BACKGROUND: We assessed attitudes towards and acceptability of male hormonal contraception among volunteers participating in a clinical trial of a prototype regimen, consisting of progestin and testosterone injections. METHODS: After completing screening, eligible men were randomly assigned to the no-treatment group (n = 40) or to receive injections of norethisterone enanthate and testosterone undecanoate or placebo at different intervals (n = 50) according to a blocked randomization list. They underwent self-administered questionnaires. RESULTS: The average age of the participants was approximately 28 years; most were involved in a stable relationship and had no children. Ninety-two percentage of the respondents thought that men and women should share responsibility for contraception and 75% said they would try a hormonal contraceptive if available. At the end of the treatment phase, 66% of the participants said that they would use such a method, and most rated its acceptability very highly; none reported it to be unacceptable. The injections themselves were indicated as the biggest disadvantage. No significant changes in sexual function or mood states were detected among the men who underwent hormone injections. CONCLUSIONS: The contraceptive tested in this study was well accepted by the participants over the course of 1 year.

Key words: acceptability/male hormonal contraception/testosterone


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