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Hum. Reprod. Advance Access originally published online on September 5, 2006
Human Reproduction 2007 22(1):97-100; doi:10.1093/humrep/del335
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Comparison of different gonadotrophin preparations in intrauterine insemination cycles for the treatment of unexplained infertility: a prospective, randomized study

A. Demirol1,3 and T. Gurgan1,2

1 Clinic Women Health, Infertility and IVF Center and 2 Department of Obstetrics and Gynecology, Reproductive Endocrinology and IVF Unit, Hacettepe University, Ankara, Turkey

3 To whom correspondence should be addressed at: Clinic Women Health, Infertility and IVF Center, Cankaya caddesi, 20/3, Cankaya, Ankara, Turkey. E-mail: ademirol{at}gmail.com

BACKGROUND: A comparison of the effectiveness of different gonadotrophin preparations in intrauterine insemination (IUI) cycles for patients with unexplained infertility was performed. METHODS: Two hundred and forty-one patients were prospectively randomized using computer-generated random numbers into three groups: 81 in the Follitropin {alpha} (Group I), 80 in the urinary FSH (uFSH) (Group II) and 80 in the hMG (Group III). The primary outcome was clinical pregnancy rate with duration of stimulation, total gonadotrophin dose, number of dominant follicles, clinical pregnancy rate, multiple pregnancy, miscarriage rate and ovarian hyperstimulation syndrome (OHSS) rate being secondary outcomes. RESULTS: Clinical pregnancy rate was significantly higher in the rFSH group (25.9% in Follitropin {alpha}, 13.8% in uFSH and 12.5% in HMG groups; P = 0.04). There was no significant difference in terms of duration of stimulation, but mean FSH dose consumed per cycle was significantly lower in the recombinant FSH (rFSH) group compared with others (825 IU in Follitropin {alpha}, 1107 IU in uFSH and 1197 IU in HMG groups; P = 0.001). The number of follicles ≥16 mm diameter was significantly higher in the rFSH group compared with the uFSH and HMG groups (2.6 in Follitropin {alpha}, 1.3 in uFSH and 1.4 in HMG groups; P = 0.001). CONCLUSION: rFSH may result in a better outcome in IUI cycles for unexplained infertility.

Key words: gonadotrophin/IUI/ovarian stimulation/recombinant FSH/unexplained infertility


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