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Hum. Reprod. Advance Access originally published online on August 1, 2007
Human Reproduction 2007 22(10):2660-2664; doi:10.1093/humrep/dem248
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Getting pregnant after tubal sterilization: surgical reversal or IVF?

An Boeckxstaens1, Paul Devroey1, John Collins2,3 and Herman Tournaye1,4

1 Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Laarbeeklaan 101, B-1090 Brussels, Belgium 2 McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada 3 Dalhousie University, Halifax, Canada B3H3J5

4 Correspondence address. Tel: +32 2 477 6699; Fax: +32 2 477 6649; E-mail: herman.tournaye{at}uzbrussel.be

BACKGROUND: When women regret having had a tubal sterilization, is the pregnancy rate higher with surgical reversal or IVF?

METHODS: This retrospective cohort study analyses the delivery rates of 163 patients undergoing IVF treatment (n = 79) or surgical reversal (n = 84). Pregnancy outcomes were obtained by reviewing medical records or contacting private physicians and patients. The life table method was used to calculate the chance of becoming pregnant and to construct cumulative pregnancy curves. Cumulative pregnancy curves are compared by log rank tests. A P-value of <0.05 is considered as statistically significant. The cost-effectiveness of the two strategies was also evaluated.

RESULTS: Patient characteristics did not differ between the two groups. The cumulative delivery rate during 72 months was 52.0% in the IVF group and 59.5% in the reversal group (ns). Age was the only factor that influenced delivery rates significantly. The cumulative delivery rate for patients aged <37 years was 52.4% after IVF and 72.2% after reversal (P = 0.012), while cumulative delivery rates for patients aged 37 years or older were, respectively, 51.4 and 36.6%, a difference that did not reach statistical significance. The average cost per delivery was {euro}11 707 for IVF, compared with {euro}6015 for surgical reversal. However, in patients aged 37 years or older the difference in cost was smaller.

CONCLUSION: Considering the cumulative delivery rates involved, surgical reversal is recommended for patients younger than 37; older patients are advised to opt for IVF.

Key words: IVF/reversal/tubal sterilization/decision making/reanastomosis

Submitted on January 2, 2007; resubmitted on May 14, 2007; accepted on May 17, 2007.


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