Skip Navigation


Hum. Reprod. Advance Access originally published online on September 28, 2007
Human Reproduction 2007 22(11):2851-2856; doi:10.1093/humrep/dem304
This Article
Right arrow Full Text
Right arrow Full Text (PDF )
Right arrow All Versions of this Article:
22/11/2851    most recent
dem304v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Huang, J.-C.
Right arrow Articles by Wu, K. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, J.-C.
Right arrow Articles by Wu, K. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Prostacyclin receptor signaling and early embryo development in the mouse

Jaou-Chen Huang1,6, Wan-Song A. Wun2, Jennifer S. Goldsby1,3, Karine Egan4, Garret A. FitzGerald4 and Kenneth K. Wu3,5

1 Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030 USA 2 Obstetrical and Gynecological Associates, Houston, Texas 77030 USA 3 Vascular Biology Research Center and Division of Hematology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030 USA 4 Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA 5 Cardiovascular and Blood Research Center, National Health Research Institutes, Zhunan, Taiwan

6 Correspondence address. Tel: +713-500-6382; Fax: +713-500-0586; E-mail: jaou-chen.huang{at}uth.tmc.edu

BACKGROUND: Prostacyclin (PGI2) plays an important role in mouse embryo development and implantation. However, it is unclear whether its action is mediated via the I prostaglandin receptor (IP).

METHODS: We compared the preimplantation development of IP deleted (IP–/–) embryos and wild-type (WT) embryos. We also evaluated the effect of iloprost, a stable PGI2 analog, and L-165041, a peroxisome proliferator activated receptor {delta} (PPAR{delta}) ligand, on IP–/– versus WT embryos. Finally, we compared the development of heterozygous IP deficient embryos carrying a normal maternal IP allele versus paternal IP allele.

RESULTS: Development of IP–/– embryos lagged behind WT embryos and was not enhanced by either the PGI2 analog or the PPAR{delta} ligand. WT embryos had slightly higher, although statistically not significant, implantation rates than IP–/– embryos. Heterozygous IP deficient embryos carrying a normal maternal IP allele showed better development and responded to the PGI2 analog, unlike those carrying the normal paternal IP allele.

CONCLUSIONS: IP receptors play an important role in preimplantation embryo development and mediate the embryo's response to exogenous PGI2. Early embryo development depends on the oocyte IP receptor.

Key words: preimplantation embryos/prostaglandins/imprinting/PPAR{delta}

Submitted on June 20, 2007; resubmitted on August 13, 2007; accepted on August 28, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.