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Hum. Reprod. Advance Access originally published online on October 27, 2006
Human Reproduction 2007 22(2):421-426; doi:10.1093/humrep/del411
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Tumour incidence in Swedish women who gave birth following IVF treatment

P. Kristiansson1,4, O. Björ2 and H. Wramsby3

1 Department of Public Health and Caring Sciences, Uppsala University, Uppsala 2 Department of Radiation Sciences, Oncology, Umeå University, Umeå and 3 Department of Women and Child Health, Karolinska Institutet, IVF Clinic, S:t Göran’s Hospital, Stockholm, Sweden

4 To whom correspondence should be addressed at: Department of Public Health and Caring Sciences, University Hospital, SE-751 85 Uppsala, Sweden. E-mail: per.kristiansson{at}pubcare.uu.se

BACKGROUND: Possible effects on maternal tumour incidence of a full-term pregnancy following IVF treatment with indicated supraphysiologic steroid and peptide hormonal levels in pregnancy remain uncertain. METHODS: National registries were used to compare incidence of non-invasive and invasive tumour disease in Swedish women with live birth following IVF treatment with women with live birth without IVF. RESULTS: The study had a mean follow-up period of 6.2 years in the IVF group and 7.8 years in the non-IVF group, and the mean gestation period (s.d.) for IVF and non-IVF group was 271.0 (21.1) days and 278.5 (14.1) days, respectively. In a multivariate Poisson regression analysis, adjusted rate ratios of 0.70 (0.52–0.92) and 0.93 (0.58–1.43) among IVF women were found for the risk of carcinoma in situ (CIS) of the cervix and breast cancer, respectively. When date of conception plus 1 and 3 years were used as start of follow-up, the rate ratios of CIS of the cervix increased to 0.77 (0.57–1.03) and 0.86 (0.60–1.19), respectively, and the corresponding figures for breast cancer decreased to 0.91 (0.58–1.42) and 0.74 (0.40–1.26). CONCLUSION: Following a relatively short follow-up period, there is little if any increased risk of premenopausal cancer development in women who gave birth after IVF treatment. The women who gave birth after IVF treatment had a decreased incidence of CIS of the cervix and breast cancer, but only the former was statistically significant. However, further studies are necessary to include longer follow-up times.

Key words: IVF/National registries/tumour incidence


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