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Hum. Reprod. Advance Access originally published online on October 25, 2006
Human Reproduction 2007 22(3):850-852; doi:10.1093/humrep/del413
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A successful IVF–pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: A Case Report

Y. Kitajima, T. Endo1, T. Hayashi, S. Ishioka, T. Baba, H. Honnma and T. Saito

Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Sapporo, Japan

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16 Chuo-ku Sapporo 060-8543, Japan. E-mail: endot{at}sapmed.ac.jp

Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an advanced ovarian mixed germ cell tumour who underwent fertility-saving surgery followed by a chemotherapy regimen of cisplatin, vinblastine and peplomycin. The patient was disease-free 8 years after initial presentation. She conceived and gestated dichorionic twins after IVF–embryo transfer. To the best of our knowledge, the patient is the first to be treated successfully with the combination chemotherapy regimen and then conceive safely using assisted reproductive technology (ART).

Key words: assisted reproduction/pregnancy/chemotherapy/cancer/germ cell tumour

Submitted on January 25, 2006; resubmitted on July 29, 2006; resubmitted on August 31, 2006; accepted on September 12, 2006.


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