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Hum. Reprod. Advance Access originally published online on December 19, 2006
Human Reproduction 2007 22(4):1095-1099; doi:10.1093/humrep/del472
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The 3D vascular status of the follicle after HCG administration is qualitatively rather than quantitatively associated with its reproductive competence

Daniel H. Mendez Lozano1, Nelly Frydman2, Jean M. Levaillant1, Stéphanie Fay1, René Frydman1 and Renato Fanchin1,3

1 Department of Obstetrics and Gynecology and Reproductive Medicine 2 Department of Biology and Genetics of Reproduction, INSERM Unit 782, Clamart, Université Paris XI, Le Kremlin-Bicêtre, France

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology and Reproductive Medicine, Hôpital Antoine Béclère, 157, rue de la Porte de Trivaux, 92141 Clamart, France. E-mail: renato.fanchin{at}abc.aphp.fr

BACKGROUND: The objective of this study was to determine whether the vascular status of a single pre-ovulatory follicle is associated quantitatively and/or qualitatively with its reproductive competence.

METHODS: We studied 61 monofollicular IVF-embryo transfer cycles. Just before single oocyte retrieval, follicle vascularization was detected by transvaginal power-Doppler, 3-dimensionally reconstructed, and analysed quantitatively by coloured/gray voxel ratio [vascularization index (VI)] and qualitatively by blood cell displacement [flow index (FI)] calculation. Cycles were sorted in two sets of two groups: low VI (≤8%, n = 44) and high VI (>8%, n = 17); low FI (≤30, n = 22) and high FI (>30, n = 39).

RESULTS: Patients' characteristics, fertilization rates, and embryo morphology were comparable in all groups. In contrast, clinical pregnancy rates/oocyte retrieval (4% versus 33%, P < 0.009) and implantation rates (11% versus 50%, P < 0.04) were markedly poorer in the low as compared to the high FI groups, respectively, but remained similar between the low and the high VI groups (22% versus 23% and 38% versus 44%, respectively).

CONCLUSIONS: A qualitative (FI) rather than quantitative (VI) relationship exists between vascular status and functional quality of the follicle after HCG administration.

Key words: blood flow/embryo implantation/follicular vascularization/power Doppler

Submitted on July 27, 2006; resubmitted on November 8, 2006; accepted on November 16, 2006.


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