Skip Navigation


Hum. Reprod. Advance Access originally published online on March 2, 2007
Human Reproduction 2007 22(6):1547-1554; doi:10.1093/humrep/dem036
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
22/6/1547    most recent
dem036v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kevenaar, M. E.
Right arrow Articles by Visser, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kevenaar, M. E.
Right arrow Articles by Visser, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women

Marlies E. Kevenaar1,7, Axel P.N. Themmen1, Joop S.E. Laven4, Barbara Sonntag5, Sharon Lie Fong4, André G. Uitterlinden1,2,3, Frank H. de Jong1, Huibert A.P. Pols1,2, Manuela Simoni6 and Jenny A. Visser1

1 Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands 2 Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands 3 Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands 4 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands 5 Department of Obstetrics and Gynaecology, Münster University Hospital, Münster, Germany 6 Institute for Reproductive Medicine, Münster University Hospital, Münster, Germany

7 To whom correspondence should be addressed at: Deptartment of Internal Medicine, Room Ee532, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Tel.: +31 10 4087346; Fax: +31 10 4635430; E-mail: m.kevenaar{at}erasmusmc.nl

BACKGROUND: In mice, anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment and decreases FSH sensitivity. Little is known about the role of AMH in human ovarian physiology. We hypothesize that in women AMH has a similar role in ovarian function as in mice and investigated this using a genetic approach.

METHODS: The association of the AMH Ile49Ser and the AMH type II receptor (AMHR2) –482 A > G polymorphisms with menstrual cycle characteristics was studied in a Dutch (n = 32) and a German (n = 21) cohort of normo-ovulatory women.

RESULTS: Carriers of the AMH Ser49 allele had higher serum estradiol (E2) levels on menstrual cycle day 3 when compared with non-carriers in the Dutch cohort (P = 0.012) and in the combined Dutch and German cohort (P = 0.03). Carriers of the AMHR2 –482G allele also had higher follicular phase E2 levels when compared with non-carriers in the Dutch cohort (P = 0.028), the German cohort (P = 0.048) and hence also the combined cohort (P = 0.012). Women carrying both AMH Ser49 and AMHR2 –482G alleles had highest E2 levels (P = 0.001). For both polymorphisms no association with serum AMH or FSH levels was observed.

CONCLUSIONS: Polymorphisms in the AMH and AMHR2 genes are associated with follicular phase E2 levels, suggesting a role for AMH in the regulation of FSH sensitivity in the human ovary.

Key words: anti-Müllerian hormone/estrogen/menstrual cycle/ovarian function/polymorphism

Submitted on November 13, 2006; resubmitted on December 22, 2006; accepted on January 22, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
M. Simoni, C.B. Tempfer, B. Destenaves, and B.C.J.M. Fauser
Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response
Hum. Reprod. Update, September 1, 2008; 14(5): 459 - 484.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Yding Andersen, M. Rosendahl, and A. G. Byskov
Concentration of Anti-Mullerian Hormone and Inhibin-B in Relation to Steroids and Age in Follicular Fluid from Small Antral Human Follicles
J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2344 - 2349.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. E. Kevenaar, J. S. E. Laven, S. L. Fong, A. G. Uitterlinden, F. H. de Jong, A. P. N. Themmen, and J. A. Visser
A Functional Anti-Mullerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients
J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1310 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B.C.J.M. Fauser, K. Diedrich, P. Devroey, and on behalf of the Evian Annual Reproduction (EVAR)
Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation
Hum. Reprod. Update, January 1, 2008; 14(1): 1 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. E. Kevenaar, A. P.N. Themmen, F. Rivadeneira, A. G. Uitterlinden, J. S.E. Laven, N. M. van Schoor, P. Lips, H. A.P. Pols, and J. A. Visser
A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
Hum. Reprod., September 1, 2007; 22(9): 2382 - 2388.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.