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Hum. Reprod. Advance Access originally published online on April 24, 2007
Human Reproduction 2007 22(7):1841-1843; doi:10.1093/humrep/dem082
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Do children born after assisted conception have less risk of developing infantile autism?

Rikke Damkjær Maimburg1,2,4 and Michael Væth3

1 Institute of Public Health, Department of Epidemiology, University of Aarhus, Vennelyst, Boulevard 6, 8000 Aarhus C, Denmark 2 Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Denmark 3 Institute of Public Health, Department of Biostatistics, University of Aarhus, Vennelyst, Boulevard 6, 8000 Aarhus C, Denmark

4 Correspondence address. Tel: +45 89 42 61 69; Fax: +45 86 13 15 80; E-mail: rmai{at}soci.au.dk

BACKGROUND: A Danish population based matched case–control study of perinatal risk factors in children with infantile autism has provided some interesting and surprising observations regarding infantile autism and children born after assisted conception.

METHODS and RESULTS: The cases (461) consisted of all children born between 1990 and 1999 and diagnosed with infantile autism in the Danish Psychiatric Central Register before February 2001. Matched controls were identified in the Danish Civil Registration System. The main exposure measures included obstetric risk factors for infantile autism. We found a 59% decreased risk for developing infantile autism among children conceived after assisted conception (odds ratio [OR] 0.41, 95% [0.19–0.89]) and a 63% decreased risk after adjusting for known risk factors for assisted conception and infantile autism (OR 0.37, 95% [0.14–0.98]).

CONCLUSION: We found that children born after assisted conception had a lower risk of developing infantile autism then their matched controls. Our observations could possibly be explained by the mother's health status before and during early pregnancy. Our findings require further investigation in larger studies.

Key words: autistic disorders/health behaviour/infertility treatment/pregnancy/assisted conception

Submitted on December 21, 2006; resubmitted on February 23, 2007; accepted on March 5, 2007.


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