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Hum. Reprod. Advance Access originally published online on June 15, 2007
Human Reproduction 2007 22(8):2088-2092; doi:10.1093/humrep/dem152
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

OPINION

Role of sperm FISH studies in the genetic reproductive advice of structural reorganization carriers

E. Anton, F. Vidal and J. Blanco1

Unitat de Biologia Cel·lular (Facultat de Biociències), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

1 Correspondence address. Tel: +34 93 581 37 28; Fax: +34 93 581 22 95; E-mail address: joan.blanco{at}uab.es

The use of fluorescence in-situ hybridization (FISH) in decondensed spermatozoa from carriers of structural chromosomal abnormalities provides a way to estimate the amount of unbalanced products. This methodology has become a tool of special interest for a better approximation of the reproductive competence of the carriers. Although there is no discussion regarding the cytogenetic value of the information obtained, the usefulness of performing individual sperm FISH studies must be weighed depending on the object of the study.

In this paper, we introduce some considerations concerning the convenience of a routine application of sperm FISH analysis in the major populations of structural reorganization carriers. For each group, the significance of the information that can be obtained and its relevance for genetic reproductive advice are discussed.

Key words: structural reorganization carriers/sperm FISH studies/meiotic segregation/interchromosomal effects

Submitted on November 22, 2006; resubmitted on May 4, 2007; accepted on May 9, 2007.


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