Skip Navigation


Hum. Reprod. Advance Access originally published online on July 18, 2007
Human Reproduction 2007 22(9):2414-2421; doi:10.1093/humrep/dem204
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
22/9/2414    most recent
dem204v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nelson, S. M.
Right arrow Articles by Fleming, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nelson, S. M.
Right arrow Articles by Fleming, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Serum anti-Müllerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles—implications for individualization of therapy

Scott M. Nelson1,3, Robin W. Yates2 and Richard Fleming1

1 Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, UK 2 Assisted Conception Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK

3 Correspondence address. Tel: +44 141 211 4706; Fax: +44 141 552 0873; E-mail: s.nelson{at}clinmed.gla.ac.uk

BACKGROUND: Serum concentrations of anti-Müllerian hormone (AMH) correlate with oocyte yield in assisted reproduction treatment (ART) cycles, however, performance of AMH for prediction of live birth is unknown.

METHODS: A total of 340 first cycle IVF/ICSI patients (median age 34.0 years, inter-quartile range 31.0–37.0 years), had basal plasma AMH and FSH measured and their predictive values for live birth and oocyte yield compared.

RESULTS: AMH predicts live birth [contribution to variance (CTV) 3.84%, P < 0.001] and oocyte yield (r = 0.71, P < 0.0001, CTV 7.3%, P < 0.0001). Compared with age and FSH, AMH performs better in prediction of live births [area under receiver operating characteristic curve (AUC) 0.62, 95% CI 0.55–0.68; FSH AUC 0.42, 95% CI 0.35–0.49; age AUC 0.48, 95% CI 0.41–0.55, P = 0.0028] and excessive response to ovarian stimulation (AMH AUC 0.90, 95% CI 0.83–0.96; FSH AUC 0.32, 95% CI 0.23–0.40; age AUC 0.57, 95% CI 0.43–0.71, P < 0.001). AMH prediction of oocyte yield is independent of age (r = –0.28, P < 0.0001, CTV 1.4%, P = 0.006), however, a significant negative interaction (CTV 3.6%, P < 0.0001) exists. AMH demonstrates improved differential distributions for non-, poor, normal and excessive ovarian responses relative to FSH and age.

CONCLUSIONS: Plasma AMH is a superior predictor of live birth and anticipated oocyte yield compared with FSH and age, facilitating individualization of therapy prior to first ART cycle.

Key words: anti-Müllerian hormone/live birth/controlled ovarian stimulation

Submitted on February 14, 2007; resubmitted on June 6, 2007; accepted on June 13, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
A. La Marca, G. Sighinolfi, D. Radi, C. Argento, E. Baraldi, A. C. Artenisio, G. Stabile, and A. Volpe
Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)
Hum. Reprod. Update, March 1, 2010; 16(2): 113 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D.A. Dumesic, M.S. Patankar, D.K. Barnett, T.G. Lesnick, B.A. Hutcherson, and D.H. Abbott
Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys
Hum. Reprod., December 1, 2009; 24(12): 3188 - 3195.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. La Marca, S. Marzotti, A. Brozzetti, G. Stabile, A. C. Artenisio, V. Bini, R. Giordano, A. De Bellis, A. Volpe, A. Falorni, et al.
Primary Ovarian Insufficiency due to Steroidogenic Cell Autoimmunity Is Associated with a Preserved Pool of Functioning Follicles
J. Clin. Endocrinol. Metab., October 1, 2009; 94(10): 3816 - 3823.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, F.J. Broekmans, A. Volpe, B.C. Fauser, N.S. Macklon, and on behalf of the ESHRE Special Interest Group for
Anti-Mullerian hormone (AMH): what do we still need to know?
Hum. Reprod., September 1, 2009; 24(9): 2264 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. Devroey, B.C.J.M. Fauser, K. Diedrich, and on behalf of the Evian Annual Reproduction (EVAR)
Approaches to improve the diagnosis and management of infertility
Hum. Reprod. Update, July 1, 2009; 15(4): 391 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. M. Nelson, R. W. Yates, H. Lyall, M. Jamieson, I. Traynor, M. Gaudoin, P. Mitchell, P. Ambrose, and R. Fleming
Anti-Mullerian hormone-based approach to controlled ovarian stimulation for assisted conception
Hum. Reprod., April 1, 2009; 24(4): 867 - 875.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Gnoth, A.N. Schuring, K. Friol, J. Tigges, P. Mallmann, and E. Godehardt
Relevance of anti-Mullerian hormone measurement in a routine IVF program
Hum. Reprod., June 1, 2008; 23(6): 1359 - 1365.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.