Skip Navigation


Hum. Reprod. Advance Access originally published online on November 2, 2007
Human Reproduction 2008 23(1):105-111; doi:10.1093/humrep/dem257
This Article
Right arrow Full Text
Right arrow Full Text (PDF )
Right arrow All Versions of this Article:
23/1/105    most recent
dem257v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Leunens, L.
Right arrow Articles by Ponjaert-Kristoffersen, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leunens, L.
Right arrow Articles by Ponjaert-Kristoffersen, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children

L. Leunens1,3, S. Celestin-Westreich1, M. Bonduelle2, I. Liebaers2 and I. Ponjaert-Kristoffersen1

1 Developmental and Lifespan Psychology, Vrije Universiteit Brussel, 1050 Brussels, Belgium 2 Academisch Ziekenhuis,Centre for Medical Genetics, Vrije Universiteit Brussel, 1090 Brussels, Belgium

3 Correspondence address. Pleinlaan 2, B-1050 Brussels, Belgium. E-mail: lize.leunens{at}vub.ac.be

BACKGROUND: This is the first follow-up study of the cognitive, psychosocial, family-relational and medical development of ICSI children at ages 8 and 10. Second-wave study results on the cognitive and motor development of 10-year-old ICSI children are discussed and compared with the outcome at 8 years.

METHODS: Developmental outcomes of 109 10-year-old singletons born through ICSI after at least 32 weeks of gestation were compared with those of 90 singletons of the same age born after spontaneous conception (SC). The outcomes were also compared with the outcomes of the children at age 8.

RESULTS: 10-year-old ICSI children obtained total, verbal and performance intelligence scores comparable to those of SC children. No significant differences were found between ICSI and SC children regarding overall motor, manual and ball skills. ICSI children and girls appear to have better balance skills than SC children and boys, respectively. With regard to long-term follow-up, the IQ results of ICSI and SC children at age 10 appear to have converged (from slightly higher scores in the ICSI children at age 8), probably indicating a decreased effect of maternal educational level or stimulating home environment in the ICSI group over time.

CONCLUSIONS: In this follow-up study, ICSI and SC children show a comparable cognitive and motor development until the age of 10. These findings are in line with those obtained at age 8.

Key words: child follow-up/ICSI/cognitive/motor development

Submitted on January 16, 2007; resubmitted on May 24, 2007; accepted on May 31, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
A. N. Andersen, E. Carlsen, and A. Loft
Trends in the use of intracytoplasmatic sperm injection marked variability between countries
Hum. Reprod. Update, August 16, 2008; (2008) dmn032v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. J. Amor and J. Halliday
A review of known imprinting syndromes and their association with assisted reproduction technologies
Hum. Reprod., August 14, 2008; (2008) den310v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Nekkebroeck, M. Bonduelle, S. Desmyttere, W. Van den Broeck, and I. Ponjaert-Kristoffersen
Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening
Hum. Reprod., July 1, 2008; 23(7): 1560 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
K.J. Middelburg, M.J. Heineman, A.F. Bos, and M. Hadders-Algra
Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review
Hum. Reprod. Update, May 1, 2008; 14(3): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Fernandez-Gonzalez, P. N. Moreira, M. Perez-Crespo, M. Sanchez-Martin, M. A. Ramirez, E. Pericuesta, A. Bilbao, P. Bermejo-Alvarez, J. d. D. Hourcade, F. R. d. Fonseca, et al.
Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring
Biol Reprod, April 1, 2008; 78(4): 761 - 772.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.