Hum. Reprod. Advance Access originally published online on July 29, 2008
Human Reproduction 2008 23(11):2506-2512; doi:10.1093/humrep/den285
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Ovarian failure following cancer treatment: current management and quality of life
1 Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK 2 Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Whitham Road, Sheffield S10 2SJ, UK 3 Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Trust, Tree Root Walk, Sheffield S10 2SF, UK 4 Section of Endocrinology and Reproduction, University of Sheffield, Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield S10 2JF, UK 5 Academic Unit of Child Health, Sheffield Children’s Hospital, University of Sheffield, Western Bank, Sheffield S10 2TH, UK 6 Department of Haematology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield S10 2JF, UK
7 Correspondence address. Tel: +44-114-2265231; Fax: +44-114-2265678; E-mail: d.greenfield{at}sheffield.ac.uk
BACKGROUND: There is a lack of evidence regarding current screening practices for incipient ovarian failure in young women following gonadotoxic therapy and the most appropriate form of estrogen replacement. This study examined the (i) prevalence and management of ovarian failure and (ii) quality-of-life implications of early menopause (EM).
METHODS: A medical case note audit for 288 women with a history of gonadotoxic therapy (aged 18–50 years) was conducted. Self-reported quality-of-life data were obtained from 178 (62%).
RESULTS: Ovarian screening was recorded in 44% of medical case notes, and ovarian failure was documented for 35%. From the self-reported data, 89/178 (50%) women reported experiencing an EM/ovarian failure. Worse menopausal symptoms were negatively associated with both sexual activity [pleasure (r = 0.29, P < 0.01), discomfort (r = 0.50, P < 0.001) and habit (r = 0.22, P < 0.05)] and general quality of life (P = 0.01). Hormone replacement therapy is the most commonly prescribed estrogen preparation; however, 34% of women with EM/ovarian failure reported not taking any replacement therapy.
CONCLUSIONS: Given the extent and impact of menopausal symptoms, further work is needed to establish systems for screening ovarian function and to determine appropriate and effective management of ovarian failure.
Key words: ovarian failure/cancer/quality of life/early menopause/gonadotoxic therapy
Submitted on February 26, 2008; resubmitted on June 12, 2008; accepted on June 18, 2008.