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Hum. Reprod. Advance Access originally published online on June 24, 2008
Human Reproduction 2008 23(8):1686-1690; doi:10.1093/humrep/den241
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

What next for preimplantation genetic screening? A clinician’s perspective

Kayhan Yakin1 and Bulent Urman

VKF American Hospital of Istanbul, Assisted Reproduction Unit, Guzelbahce Sokak No. 20, Nisantasi, Istanbul 34365, Turkey

1 Correspondence address. Tel: +90-212-3112000; Fax: +90-212-3112339; E-mail: kyakin{at}yahoo.com, kayhany{at}amerikanhastanesi.com.tr, kyakin{at}hotmail.com

Preimplantation genetic screening (PGS) is a technique that has been introduced into clinical practice to screen and eliminate aneuploid embryos from transfer with the intention to improve implantation rates and decrease pregnancy wastage. Although practiced widely throughout the world, PGS unfortunately has been adopted without being subjected to rigorous scientific validation. Data from recent randomized trials have shed doubt on the efficacy of the procedure when used in women with advanced age, one of the target populations for PGS. Other purported indications for the application of this complicated technique such as recurrent implantation failure and recurrent spontaneous abortion have not been subjected to randomized controlled trials. For the best interest of patients, we feel it is timely for a debate regarding the efficacy and safety of PGS.

Key words: preimplantation genetic screening/aneuploidy/advanced maternal age/recurrent implantation failure/recurrent spontaneous abortion


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