Skip Navigation


Hum. Reprod. Advance Access originally published online on May 15, 2008
Human Reproduction 2008 23(8):1719-1723; doi:10.1093/humrep/den100
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
23/8/1719    most recent
den100v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tiboni, G.M.
Right arrow Articles by Giampietro, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tiboni, G.M.
Right arrow Articles by Giampietro, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Effects of the aromatase inhibitor letrozole on in utero development in rats

G.M. Tiboni1,3, F. Marotta1, C. Rossi2 and F. Giampietro1

1 Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell’Invecchiamento, Facoltà di Medicina e Chirurgia, Università "G. d’Annunzio", Chieti-Pescara, Ospedale Clinicizzato "SS. Annunziata", Via dei Vestini, 66013 Chieti, Italy 2 Centro Scienze dell'Invecchiamento (Ce.Si.), Università degli Studi "G. d’Annunzio", Chieti-Pescara, Via Colle dell'Ara, 66013, Chieti, Italy

3 Correspondence address. Tel: +39-0871-540034; Fax: +39-0871-540037. E-mail: tiboni{at}unich.it

BACKGROUND: The aromatase inhibitor letrozole has recently been identified as a promising ovulation-inducing agent. As information regarding possible adverse effects on gestation outcome is limited, the present study was undertaken to evaluate the developmental toxicity potential of letrozole in the rat.

METHODS: Pregnant Sprague–Dawley rats were exposed via drinking water to letrozole at 0 (control group), 0.01, 0.02, or 0.04 mg/kg during the period of organogenesis. Developmental endpoints, including intrauterine mortality, fetal growth and incidence of structural abnormalities, were evaluated near the end of gestation.

RESULTS: Major treatment-related effects included: (i) a dose-dependent increase in post-implantation loss, which reached 47.2% following exposure to 0.04 mg/kg letrozole; (ii) minor vertebral anomalies affecting 32.2, 29.3 and 42.2% of fetuses exposed to 0.01, 0.02 and 0.04 mg/kg, respectively.

CONCLUSION: Gestational exposure to doses of letrozole that are equal to or lower than the daily recommended human dose has toxic effects on prenatal development in rats.

Key words: letrozole/rat/developmental toxicity

Submitted on November 2, 2007; resubmitted on February 25, 2008; accepted on March 4, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
G.M. Tiboni, F. Marotta, A.P. Castigliego, and C. Rossi
Impact of estrogen replacement on letrozole-induced embryopathic effects
Hum. Reprod., November 1, 2009; 24(11): 2688 - 2692.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M.F.G. Verberg, N.S. Macklon, G. Nargund, R. Frydman, P. Devroey, F.J. Broekmans, and B.C.J.M. Fauser
Mild ovarian stimulation for IVF
Hum. Reprod. Update, January 1, 2009; 15(1): 13 - 29.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.