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Hum. Reprod. Advance Access originally published online on June 24, 2008
Human Reproduction 2008 23(8):1924-1931; doi:10.1093/humrep/den239
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Soo Jin Chae1, Jin Ju Kim1, Young Min Choi1,2,3, Kyu Ri Hwang1, Byung Chul Jee1,2, Seung Yup Ku1,2, Chang Suk Suh1,2, Seok Hyun Kim1,2, Jung Gu Kim1 and Shin Yong Moon1,2

1 Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110–744, South Korea 2 Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea

3 Correspondence address. Fax: +82-2-762-3599; E-mail: ymchoi{at}snu.ac.kr

BACKGROUND: We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women.

METHODS: We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups.

RESULTS: The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P < 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS.

CONCLUSIONS: Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities.

Key words: polycystic ovary syndrome/PCOS subgroups/metabolic syndrome/insulin resistance/hyperandrogenism

Submitted on March 29, 2008; resubmitted on May 16, 2008; accepted on May 23, 2008.


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