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Hum. Reprod. Advance Access originally published online on October 22, 2008
Human Reproduction 2009 24(1):37-44; doi:10.1093/humrep/den361
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital

S. Menon1, N. Rives2,5, N. Mousset-Siméon1, L. Sibert3, J.P. Vannier4, S. Mazurier1, L. Massé1, V. Duchesne1 and B. Macé1

1 Laboratoire de Biologie de la Reproduction—CECOS, Groupe de recherche EA 4308 ‘Spermatogenesis and Male Gamete Quality’, Rouen University Hospital, 76031 Rouen cedex, France 2 Laboratoire de Biologie de la Reproduction—CECOS, Groupe de recherche EA 4308 ‘Spermatogenesis and male gamete quality’, Centre d'Investigation Clinique, INSERM 0204, Rouen University Hospital, 76031 Rouen cedex, France 3 Service d'Urologie, Groupe de recherche EA 4308 ‘Spermatogenesis and male gamete quality’, Rouen University Hospital, 76031 Rouen cedex, France 4 Service d'Immuno-Hémato-Oncologie pédiatrique, Rouen University Hospital, 76031 Rouen cedex, France

5 Correspondence address. Tel: +33-2-32-888225; Fax: +33-2-35-982007; E-mail: nathalie.rives{at}chu-rouen.fr

BACKGROUND: Sperm banking is a suitable procedure to prevent infertility after cancer therapy in male adolescents. We evaluated the feasibility of semen preservation in 156 adolescents aged between 13 and 20 years and then we assessed fertility outcome after treatment.

METHODS: Age, urogenital history, indications for cryopreservation, histological diagnosis and semen parameters were recorded. Fertility status after treatment was assessed by a questionnaire addressed to those patients who had utilized sperm storage. Post-treatment semen analysis was performed for 22 patients.

RESULTS: Cryopreservation was possible in 88.5% of cases. Azoospermia was detected in 2.6% of the patients at the time of diagnosis. Malignant disease accounted for 84% of our male adolescents. In this type of disease, semen parameters were significantly altered only among patients with metastatic malignant bone tumour. After treatment, nine patients presented azoospermia, five patients achieved pregnancy spontaneously, two achieved it after assisted reproductive technique using fresh ejaculated spermatozoa and one following sperm donation. Three failed with cryopreserved sperm.

CONCLUSIONS: Semen cryopreservation is possible for most adolescents and, regardless of disease type, may be a means of preserving fertility prior to gonadotoxic treatment that might impair the spermatogenesis process.

Key words: adolescents/cryopreservation/fertility/outcome/semen parameters

Submitted on January 30, 2008; resubmitted on July 30, 2008; accepted on August 4, 2008.


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N. Rives
Reply: Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital
Hum. Reprod., October 24, 2009; (2009) dep331v1.
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Home page
 Hum ReprodHome page
L. Carmignani
Re: Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital
Hum. Reprod., September 1, 2009; 24(9): 2384 - 2385.
[Full Text] [PDF]


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