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Hum. Reprod. Advance Access originally published online on June 16, 2009
Human Reproduction 2009 24(10):2656-2659; doi:10.1093/humrep/dep212
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis

Hoon Kim1, Seung Yup Ku1,2, Sung Hoon Kim3, Gyoung Hoon Lee4, Young Min Choi1,2,6, Jong Mee Kim1, Taek Hoo Lee5 and Shin Yong Moon1,2

1 Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110–744, South Korea 2 The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea 3 Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, South Korea 4 Department of Obstetrics and Gynecology, Gachon University of Medicine and Science, Incheon, South Korea 5 Department of Obstetrics and Gynecology, Kyungpook University College of Medicine, Taegu, South Korea

6 Correspondence address. Fax: +82-2-762-3599; E-mail: ymchoi{at}snu.ac.kr

BACKGROUND: Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to endometriosis. This study was designed to evaluate the association between the Glu298Asp polymorphism of the NOS3 and advanced stage endometriosis.

METHODS: This study consisted of 299 women with advanced stage endometriosis and 459 control women without endometriosis in a Korean population. Genotyping results of the Glu298Asp polymorphism of the NOS3 were analyzed between the endometriosis and control group.

RESULTS: The genotypic frequencies were significantly different between women with and without endometriosis. The frequency of the non-GG genotype (GT + TT) was higher in the endometriosis group than in the control group (P = 0.001).

CONCLUSION: These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.

Key words: endometriosis/polymorphism/eNOS/NOS3

Submitted on January 2, 2009; resubmitted on May 18, 2009; accepted on May 20, 2009.


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