Skip Navigation


Hum. Reprod. Advance Access originally published online on January 21, 2009
Human Reproduction 2009 24(5):1075-1079; doi:10.1093/humrep/den485
This Article
Right arrow Full Text
Right arrow Full Text (PDF )
Right arrow All Versions of this Article:
24/5/1075    most recent
den485v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Hum. Reprod.
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lindborg, L.
Right arrow Articles by Strandell, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lindborg, L.
Right arrow Articles by Strandell, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Influence of HyCoSy on spontaneous pregnancy: a randomized controlled trial

L. Lindborg1,3, J. Thorburn1, C. Bergh1 and A. Strandell2

1 Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, 41345 Göteborg, Sweden 2 Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Gothenburg, 41345, Göteborg, Sweden

3 Correspondence address. E-mail: lena.lindborg{at}vgregion.se

BACKGROUND: The aim of the study was to test whether the use of sonography contrast could enhance the chance of spontaneous clinical pregnancy in women undergoing subfertility investigation.

METHODS: Couples with at least 1 year of infertility who were scheduled for a consultation including a hysterosalpingo contrast sonography (HyCoSy) were invited to participate in the study. We compared flushing with water-soluble contrast medium (WSCM) versus no flushing. Randomization sequence was computer generated, stratified for age and group allocation was concealed. Primary outcome was clinical pregnancy defined as a sonographically visible fetal sac, detected within 6 months from randomization. Secondary outcomes were spontaneous miscarriage and birth. Exclusion criteria were female age ≥40 years, severe male infertility, previously known severe tubal infertility and suspected anovulation.

RESULTS: The mean age of the study population (n = 334) was 31.9 years. Duration of infertility was 2.1 years. The clinical pregnancy rate was 29.2% in the HyCoSy group and 26.5% in the non-flushing group, the difference being 2.7% (95% confidence interval –6.9 to 12.3%, P = 0.63).

CONCLUSION: The clinical impression of an enhanced pregnancy rate after performing HyCoSy could not be confirmed. Tubal investigation with sonography using water-soluble contrast has a function as a diagnostic procedure but not in terms of increasing pregnancy rates in subfertile patients. Trial registration number: ISRCTN20715945 [controlled-trials.com] .

Key words: hysterosalpingo contrast sonography/transvaginal ultrasound/pregnancy/subfertility

Submitted on June 25, 2008; resubmitted on November 25, 2008; accepted on December 15, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in Hum. Reprod.:

Editor's Choice
André Van Steirteghem
Hum. Reprod. 2009 24: 1007. [Extract] [Full Text]  





Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.