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Human Reproduction, Vol. 3, No. 8, pp. 935-938, 1988
© 1988 European Society of Human Reproduction and Embryology

research-article

Effects of preovulatory tamoxifen in regularly cycling women on folliculogenesis, oocyte recovery and luteal function

Sam S. Thatcher2, Ros E. Angell, John D. west, Anna F. Glasier, Rodney w. Kelly1, Stephen G. Hillier and David T. Baird

Department of Obstetrics and Gynaecology University of Edinburgh, Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW, UK 1MRC Unit of Reproductive Biology, University of Edinburgh, Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW, UK

Correspondence: 2Present address and address for correspondence: Department of Obstetrics and Gynecology, ESTU College of Medicine, Johnson City, TN 37614, USA

Forty women undergoing elective sterilization and oocyte donation were randomized in a trial to study the effects of administration of 30 mg of tamoxifen 12 h before injection of human chorionic gonadotrophin and 48 h before oocyte capture. Cycles were regulated for advanced operative scheduling with norethisterone given in the luteal phase of the previous cyde and 150 mg of clomiphene given in the early follicular phase of the recovery cycle. Tamoxifen cycles showed a delay of peak urinary oestrone excretion by 2 days, associated with a slight decrease in total excretion. Tamoxifen administration lengthened treatment cycles by 0.5 days and the luteal phase by 0.4 days. The urinary excretion peak of pregnanediol was 3 days later than in controls. Total pregnanediol excretion was slightly elevated. There were no differences in oocyte recovery rate although cleavage rate was decreased (0.84 versus 0.65, not significant at P ≥ 0.05). Intrafofficular oestradlol levels were similar (794 ± 97 versus 735 ± 102 ng/ml). Intrafollicular progesterone levels were marginally lower in tamoxifen cycles (3.5 ± 0.5 versus 2.3 ± 0.8 g/ml).

Key words: anti-oestrogen/IVF/luteal/ovary/preovulatory


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